Whitcomb DC

No ORCID on file · 7 papers in corpus · active 2008-2025
2025
The journal of pain ·doi:10.1016/j.jpain.2024.104754

Recurrent acute and chronic pancreatitis (RAP, CP) are complex, progressive inflammatory diseases with variable pain experiences impacting patient function and quality of life. The genetic variants and pain pathways in patients contributing…

2017
Digestive diseases and sciences ·doi:10.1007/s10620-017-4621-z

Background/objectivesOur aim was to validate recent epidemiologic trends and describe the distribution of TIGAR-O risk factors in chronic pancreatitis (CP) patients.MethodsThe NAPS-2 Continuation and Validation (NAPS2-CV) study prospectivel…

2016
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] ·doi:10.1016/j.pan.2016.02.001

BackgroundA definition of chronic pancreatitis (CP) is needed for diagnosis and distinguishing CP from other disorders. Previous definitions focused on morphology. Advances in epidemiology, genetics, molecular biology, modeling and other di…

2012
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association ·doi:10.1016/j.cgh.2011.12.040

Background & aimsEndoscopic therapy (ET) frequently is used to treat patients with painful chronic pancreatitis (CP), but little is known about outcomes of patients for whom ET was not successful who then underwent surgery, or outcomes afte…

2012
Nature reviews. Gastroenterology & hepatology ·doi:10.1038/nrgastro.2012.100

Personalized medicine is a new framework for medical care that involves modelling and simulation of a disease on the basis of its underlying mechanisms. This strategy must replace the 20(th) century paradigm of defining disease by pathology…

2008
World journal of gastroenterology ·doi:10.3748/wjg.14.4486

AimTo test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S or alcohol are necessary co-factors in …

2008
Archives of pathology & laboratory medicine ·doi:10.5858/2008-132-48-sigfli

ContextAutoimmune pancreatitis is an uncommon, inflammatory disease of the pancreas that presents with clinical features, such as painless jaundice and a pancreatic mass, similar to those caused by pancreatic cancer. Patients with autoimmun…