Wu L

AIMS: This study aims to develop and validate a Multi-Dimensional Computational Screening (MDCS) strategy to identify bioactive components by jointly considering target affinity, exposure potential, and safety, using Liangdi decoction (LDD)…

Precise regulation of alternative splicing (AS) of maternal mRNAs is crucial for maintaining mRNA homeostasis and for acquiring oocyte competence. However, the regulatory factors and mechanisms of AS regulating oocyte competence and human f…

BACKGROUND: Currently, CA125 combined with other biomarkers significantly outperforms CA125 alone in diagnosing endometriosis (EM), but the efficiency of combined diagnosis remains unclear. This network meta-analysis compared the accuracy o…

PURPOSE: The purpose of this experiment is to study the impact of dexmedetomidine combined with esketamine on postoperative fatigue in patients who undergo total laparoscopic hysterectomy. PATIENTS AND METHODS: A total of 176 patients who …

OBJECTIVE: This retrospective cohort study aimed to evaluate whether a goal-directed weight loss intervention prior to assisted reproductive technology (ART) improves live birth rates compared with immediate in vitro fertilization (IVF) wit…

Patients with endometriosis have greater risk of infertility, which is associated with compromised ovarian function. Dysfunction in follicular granulosa cells and hyperactivation of oestrogen receptor beta (ERβ) are evident in endometriosis…

ObjectivesThis study aimed to report a concept analysis of fertility protection and elucidate a current definition.MethodsThis study adopted Rodgers's evolutionary and inductive method of concept analysis. Literature from January 1990 to Ma…

Preeclampsia (PE) is a major cause of maternal and perinatal morbidity. Because abnormal fat distribution is closely related to metabolic dysfunction, vascular injury, and hypertensive disorders during pregnancy, clarifying its genetic rela…

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

BACKGROUND: Non-neoplastic gynecological diseases substantially impact women of childbearing age (WCBA), contributing to global burden. Despite growing awareness, disparities in healthcare access remain widespread across regions and socioec…

OBJECTIVE: To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. METHODS: A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy admin…

OBJECTIVE: This study aimed to investigate the mechanisms underlying Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1, encoding SF-1) hypomethylation in endometriosis (EMs) and to evaluate the effects of Luoshi Neiyi Prescription (LSNYP…

BACKGROUND: Luoshi Neiyi prescription (LSNYP) is a traditional Chinese medicine that has a clinical effect on endometriosis (EMs). This study combined network pharmacology with experimental validation to explore its potential molecular mech…

Endometriosis-associated ovarian cancer (EAOC) is a rare subtype of ovarian cancer arising from the malignant transformation of endometriosis (EMS). Despite growing clinical awareness, its underlying pathogenic mechanisms are not fully unde…

Sleep disorders and deficiencies can up-regulate pro-inflammatory mediators, but their potential adverse impact on ovarian function remains not fully understood. In this study, we investigated the immunoregulatory mechanisms underlying slee…

Abstract Objective To investigate the expression and clinical significance of systemic inflammatory indices and serum CA-125 in endometriosis, and to compare their diagnostic efficacy. Methods Clinical data were collected from 252 pat…

BACKGROUND AND AIMS: Menstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, an…

Endometrial immune disorders create an inhospitable endometrial environment for embryonic nidation in endometriosis. CD8 + tissue resident memory T cells (CD8 +TRM) are abundant tissue resident immune cells in endometrium, but the effect of…

Abdominal wall scar endometriosis (AWE) is a rare endometriosis that usually occurs after gynecological or obstetric surgery and for which surgical resection is the standard treatment. For large tissue defects after resection, abdominal wal…

BACKGROUND: Infertility poses a substantial societal and economic burden; however, current preventive strategies are limited. Recently, the relationship between gut microbiota and infertility has garnered increasing attention. The dietary i…

BACKGROUND: Endometriosis is a chronic inflammatory disease with a prevalence of approximately 10% in women of childbearing age. Metabolic pathways have been demonstrated by previous studies to be potential avenues for the development of ne…

BACKGROUND: Endometriosis (EMS) is a common chronic gynecological disorder that increases the risk of ovarian cancer by approximately threefold. However, the molecular mechanisms underlying this association remain unclear. METHODS: Mendelia…

OBJECTIVES: The aim of this study was to cross-culturally translate a questionnaire about gynecological and pelvic pain symptoms (ENDOPAIN-4D) patient-reported outcome measurement (PROM) into Chinese and evaluate its reliability and validit…

OBJECTIVE: To compare single versus double autologous platelet-rich plasma (PRP) intrauterine infusion effects on endometrial receptivity and pregnancy outcomes in patients with thin endometrium. METHODS: This randomized controlled trial i…