Chang K

No ORCID on file · 9 papers in corpus · active 2012-2024

Study types

  • article 4
  • other 1
  • preprint 1

Condition tags

  • endometriosis 6
  • infertility 2
  • bowel_endometriosis 1
other 2024
Expanding the genetic landscape of endometriosis: Integrative -omics analyses uncover key pathways from a multi-ancestry study of over 900,000 women
medRxiv : the preprint server for health sciences ·doi:10.1101/2024.11.26.24316723

We report the findings of a genome-wide association study (GWAS) meta-analysis of endometriosis consisting of a large portion (31%) of non-European samples across 14 biobanks worldwide as part of the Global Biobank Meta-Analysis Initiative …

article 2024
Extracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis
Cell communication and signaling : CCS ·doi:10.1186/s12964-023-01415-7

BACKGROUND: As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions. Succinate accumulation in the cytoplasm is commonly associated w…

article 2024
Intraoperative dual laparoscopy and neo-rectoscopy for precise excision of bowel endometriosis
Endoscopy ·doi:10.1055/a-2440-6251
2024
NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment.
ImmunoTargets and therapy ·doi:10.2147/itt.s495564

IntroductionThe NLRP3 inflammasome has been implicated in the initiation of inflammation and tumorigenesis; however, its role in epithelial ovarian cancer (EOC) remains unclear.MethodsThis study employed high-throughput sequencing data, ELI…

article 2024
The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating β-catenin
Cell communication and signaling : CCS ·doi:10.1186/s12964-024-01683-x

OBJECTIVES: Interleukin 33 (IL-33) is a crucial inflammatory factor that functions as an alarm signal in endometriosis (EMs). Epithelial-mesenchymal transition (EMT), a process related to inflammatory signals, intracellular reactive oxygen …

article 2023
Distinct subtypes of endometriosis identified based on stromal-immune microenvironment and gene expression: implications for hormone therapy
Frontiers in immunology ·doi:10.3389/fimmu.2023.1133672

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory condition that is highly heterogeneous. Current clinical staging fails to accurately predict drug responses and prognosis. In this study, we aimed to reveal the heterogeneity of ecto…

preprint 2023
Extracellular Succinate Derived From Ectopic Milieu Drives Adhesion and Implantation Growth of Endometrial stromal cells via the SUCNR1 signal in endometriosis
·doi:10.21203/rs.3.rs-3303001/v1

Abstract Background As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions. Succinate accumulation in the cytoplasm is commonly asso…

2016
DNA methylation promotes paired box 2 expression via myeloid zinc finger 1 in endometrial cancer.
Oncotarget ·doi:10.18632/oncotarget.12626

This work investigated the role of paired box 2 (PAX2) in endometrial cancer and its epigenetic regulation mechanism. Endometrial cancer tissues and cell lines exhibited increased PAX2 expression compared with hyperplasia, normal endometriu…

2012
Does risk for ovarian malignancy algorithm excel human epididymis protein 4 and CA125 in predicting epithelial ovarian cancer: a meta-analysis.
BMC cancer ·doi:10.1186/1471-2407-12-258

BackgroundsRisk for Ovarian Malignancy Algorithm (ROMA) and Human epididymis protein 4 (HE4) appear to be promising predictors for epithelial ovarian cancer (EOC), however, conflicting results exist in the diagnostic performance comparison …