Background/Objectives: Gastrointestinal (GI) symptoms, including abdominal pain, bloating, altered stool pattern, dyschezia, and nausea, are frequent in women with endometriosis and may persist despite conventional gynecological treatment. …
Background: The individual and social burden of endometriosis is high, and the diagnosis is usually delayed by 7-10 years. Menstrual effluent (ME) represents an accessible and uniquely informative biofluid. This systematic review evaluated …
BACKGROUND: Endometriosis is a chronic inflammatory and estrogen-dependent disease in which oxidative stress, immune dysregulation, and lesion-supportive microenvironmental signaling contribute to lesion development. N-acetylcysteine (NAC),…
Bartholin gland carcinoma (BGC) is a rare malignancy, comprising 3-7% of vulvar cancers and <1% of gynecologic tumors. Due to its low incidence, high-level evidence is lacking, and management is largely extrapolated from vulvar cancer guide…
Adenomyosis (AM) is a hormonally responsive uterine disorder defined by ectopic endometrial tissue within the myometrium, causing pain, abnormal bleeding, and subfertility. Non-coding RNAs (ncRNAs)-including microRNAs (miRNAs), long non-cod…
Ovarian carcinoma is a gynecological cancer with poor long-term survival rates when detected at advanced disease stages. Early symptoms are non-specific, and currently, there are no adequate strategies to identify this disease at an early s…
2019 wurden in deutschen Krankenhäusern insgesamt 748492 Geburten registriert, 3 Jahre zuvor wurden knapp 133000 Patient*innen mit Mammakarzinom vollstationär behandelt 1 2. Ein Uterus myomatosus kann ab dem Alter von 50 Jahren bei mehr als…
In der Praxis stellen sich fast 30% der prämenopausalen Frauen und 75% der postmenopausalen Frauen wegen abnormen uterinen Blutungen vor. Diese sind häufig Symptom verschiedener benigner und prämaligner Veränderungen des Endometriums. Anhan…
Background: Dickkopf-1 protein (Dkk1), a major inhibitor of Wnt/-catenin signaling, is a secretory glycoprotein that has been found to be involved in the pathogenesis of several human diseases and to provide a promising diagnostic and thera…
Einleitung: Trotz immer besserer medizinischer und operativer Therapiemaßnahmen bleibt eine adäquate Schmerztherapie für viele gynäkologische Krankheitsbilder eine He-rausforderung. Neue patientenfokussierte Testsysteme können dabei zur Ver…
Die Endometriose ist eine gynäkologische Erkrankung, welche durch das zyklische, östrogenabhängige Wachstum von Endometrioseherden außerhalb der Gebärmutterhöhle charakterisiert ist. In zahlreichen tierexperimentellen Studien wurde das Wach…
Updated by: Diagnostik und Therapie benigner und prämaligner Veränderungen des EndometriumsFrauenheilkunde up2date 2019; 13(06): 511-529DOI: 10.1055/a-0986-5884
BackgroundThe role of estrogen receptor beta (ERβ) in pathogenesis of endometriosis remains to be elucidated. In this study, we have examined the expression of the four main ERβ transcript isoforms in human endometrial tissue in women with …
AimEndometriosis is a frequent benign disease of women in reproductive age. An infiltration of the spatium rectovaginal is rare, but if it occurs, in up to 73% the rectum is involved. If there is the indication for surgery, a partial resect…