Wang S

STUDY QUESTION: Can third-generation sequencing (TGS)-based polar body (PB) analysis serve as a viable alternative to conventional trophectoderm (TE) biopsy for preimplantation genetic testing for aneuploidy (PGT-A)? SUMMARY ANSWER: This s…

Crystals or stones within the gallbladder wall in patients with gallbladder stones (GBS) have been occasionally reported, but their clinical features and aetiology remain unclear. This retrospective study analysed 323 consecutive patients w…

INTRODUCTION: This study aimed to elucidate the molecular mechanisms underlying cervical precancerous lesions by employing bioinformatic approaches to identify key genes and signaling pathways. METHODS: A comprehensive strategy was adopted…

OBJECTIVE: Advanced gastric cancer remains highly refractory to therapy, with limited immunotherapy efficacy due to tumor microenvironment heterogeneity. Primary cilia, microtubule-based organelles involved in tumor progression, remain insu…

Endometriosis is a prevalent chronic gynecological disease that poses significant challenges for treatment due to its extensive lesions, diverse morphology, unknown etiology, and tendency for recurrence. In the early 21st century, the stem …

Endometriosis is a benign disease with similar characteristics to tumors. Recent studies have found that the erythropoietin-producing hepatoma receptor A2 (EphA2) has the dual effect of promoting tumor and inhibiting tumor. The objective of…

BACKGROUND: Ovarian cysts are common in reproductive-aged women and may affect ovarian reserve, thereby impacting fertility potential. This study aimed to evaluate the differential impact of various ovarian cyst types and sizes on ovarian r…

Acanthamoeba keratitis (AK) is a rare corneal disease that can lead to permanent visual impairment. Its incidence is relatively low when compared with that of other forms of infectious keratitis. As early clinical diagnosis of AK is challen…

Macrophage metabolic reprogramming refers to the process by which macrophages adjust their physiological pathways to meet survival and functional demands in different immune microenvironments. This involves a range of metabolic pathways, in…

Macrophages are multifunctional immune cells distributed throughout the whole body, and they have functions in antigen presentation, phagocytosis, killing, and immune regulation. As the most widely studied molecule in the netrin family, net…

Lipidomics, an emerging field in medical research, has deepened our understanding of lipid metabolism, signal transduction pathways, and intercellular communication through qualitative and quantitative analyses of patient lipid profiles. It…

Ovarian hyperstimulation syndrome (OHSS) is a severe complication of controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment, characterized by increased capillary permeability. Vascular endothelial growth fac…

The aim of this study is to investigate the characteristics and etiology of endometrial hyperemia in patients with polycystic ovary syndrome (PCOS) through two complementary approaches: clinical data analysis to characterize endometrial hyp…

Tumor-associated neutrophils (TANs) contribute to breast cancer (BC) progression, and aquaporin 9 (AQP9) plays a critical role in tumor development. However, the interactions between TANs and AQP9 in BC are poorly understood. Bioinformatics…

STUDY QUESTION: What molecular mechanisms underlie the decline in ovarian reserve as the number and quality of oocytes decrease in patients with ovarian endometriomas (OEM)? SUMMARY ANSWER: Elevated expression of the let-7 micro(mi)RNAs in…

RATIONALE: Dyspareunia is a common disease affecting the physical and mental health of individuals. There are several reasons for dyspareunia. It is essential to identify the causes of dyspareunia and to implement targeted treatments. PATI…

Cross-disease genome-wide association studies (GWASs) unveil pleiotropic loci, mostly situated within the non-coding genome, each of which exerts pleiotropic effects across multiple diseases. However, the challenge "W-H-W" (namely, whether,…

This study aims to present a case of uterine adenomyosis accompanied by multiple hemorrhagic cerebral infarctions (CIs), summarize therapeutic experiences based on the literature review, and improve the clinical diagnosis and treatment of m…

Virulence factor genes (VFGs) play pivotal roles in bacterial infections and have been identified within the human gut microbiota. However, their involvement in chronic diseases remains poorly understood. Here, we establish an expanded VFG …

INTRODUCTION: Menstrual health is a key patient-reported outcome beyond its importance as a general indicator of health and fertility. However, menstrual function was not measured in the clinical trials of COVID-19 vaccines. The purpose of …

Over the years, obesity has become more commonplace and has had a substantial impact on several medical specialties, including reproductive medicine. The potential correlation between the visceral adiposity index (VAI) and infertility has y…

OBJECTIVES: To compare the accuracy of transvaginal ultrasound (TVUS) with laparoscopy in detecting and characterizing uterosacral ligament (USL) nodules of deep infiltrative endometriosis (DIE) between patients with and without pouch of Do…

BACKGROUND: A newly generic microspheres, sustained-release formulation of triptorelin acetate 3.75 mg has been developed. OBJECTIVES: To evaluate the efficacy, pharmacokinetics, and safety of triptorelin 1-month formulation in Chinese pat…

BACKGROUND: To evaluate the impact of embryo quality and quantity, specifically a poor quality embryo (PQE) in combination with a good quality embryo (GQE), by double embryo transfer (DET) on the live birth rate (LBR) and neonatal outcomes …