Ryan M. Marquardt

ORCID: 0000-0002-6597-4506 · 13 papers in corpus · active 2019-2025

Study types

  • other 5
  • article 3
  • review 3
  • preprint 2

Condition tags

  • endometriosis 12
  • infertility 10
  • mesh:D004715 7
  • mesh:D017699 1
  • adenomyosis 1
other 2025
Nature communications ·doi:10.1038/s41467-025-57173-2

Over 75% of failed pregnancies involve implantation defects. Growth factor receptor-bound protein 2 (GRB2) is an adaptor protein involved in signal transduction and cell communication. Here we show that the expression of GRB2 protein is low…

other 2025
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2510060122

Pregnancy requires a supportive uterine environment facilitated by steroid hormone-regulated differentiation of endometrial stromal fibroblasts into decidual cells and tight control of inflammation. Serum response factor (SRF) is a widely e…

article 2025
The Journal of clinical investigation ·doi:10.1172/jci193212

Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a coregulator of uterin…

review 2023
Endocrine reviews ·doi:10.1210/endrev/bnad020

Endometriosis is a prevalent gynecological condition associated with pelvic pain and infertility. Despite more than a century of research, the etiology of endometriosis still eludes scientific consensus. This lack of clarity has resulted in…

other 2022
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-022-00980-5

Endometriosis is a condition of the female reproductive tract characterized by endometrium-like tissue growing outside the uterus. Though it is a common cause of pelvic pain and infertility, there is currently no reliable noninvasive method…

other 2022
International journal of molecular sciences ·doi:10.3390/ijms23116067

A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich interaction domain 1A (ARID1A) must be properly expressed to main…

other 2022
Nature communications ·doi:10.1038/s41467-022-28608-x

Female subfertility is highly associated with endometriosis. Endometrial progesterone resistance is suggested as a crucial element in the development of endometrial diseases. We report that MIG-6 is downregulated in the endometrium of infer…

review 2020
Seminars in reproductive medicine ·doi:10.1055/s-0040-1718741

Adenomyosis is a nonmalignant uterine disorder in which endometrial tissue exists within and grows into the myometrium. Animal models have generated limited insight into the still-unclear pathogenesis of adenomyosis, provided a platform for…

preprint 2020
·doi:10.1101/2020.09.23.308528

Abstract Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in …

article 2020
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202002178r

Though endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in mice that…

article 2020
·doi:10.2139/ssrn.3639611
preprint 2020
·doi:10.21203/rs.3.rs-95903/v1

Abstract Female subfertility is highly associated with endometriosis. Although the exact etiology of endometriosis-related infertility remains to be determined, endometrial progesterone resistance has recently been suggested as a crucial el…

review 2019
International journal of molecular sciences ·doi:10.3390/ijms20153822

In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptiv…