Rakesh Sharma — Endo Lab

article 2005

Effect of Tumor Necrosis Factor Induced Alterations in Microtubule and Chromosomal Alignment of Metaphase II Oocyte— Possible Role in Endometriosis Associated Infertility

·doi:10.1016/j.fertnstert.2005.07.1040

article 2005

Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro

Reproductive BioMedicine Online ·doi:10.1016/s1472-6483(10)61170-4

To evaluate the effect of peritoneal fluid (PF) on preimplantation mouse embryo development and apoptosis, PF was obtained from women presenting with (n = 7) and without endometriosis (n = 7). Mouse embryos were cultured to the blastocyst s…

article 2005

Infliximab may reverse the toxic effects induced by tumor necrosis factor alpha in human spermatozoa: an in vitro model

Fertility and sterility ·doi:10.1016/j.fertnstert.2004.11.068

ObjectiveTo examine the toxic effects of tumor necrosis factor alpha (TNF-alpha) on ejaculated spermatozoa and evaluate the ability of infliximab to reverse these effects.DesignProspective controlled study.SettingCleveland Clinic Foundation…

article 2005

Modulation of Preimplantation Embryo Development and Apoptosis by Peritoneal Fluid From Patients With Endometriosis

·doi:10.1016/j.fertnstert.2005.07.1021

review 2005

Oxidative stress and its implications in female infertility - a clinician's perspective

Reproductive BioMedicine Online ·doi:10.1016/s1472-6483(10)61174-1

Reactive oxygen species (ROS) have a role in the modulation of gamete quality and gamete interaction. Generation of ROS is inherent in spermatozoa and contaminating leukocytes. ROS influence spermatozoa, oocytes, embryos and their environme…

article 2005

Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients*

Human Reproduction ·doi:10.1093/humrep/dei376

BACKGROUND: Leptin influences the proinflammatory immune responses and has angiogenic activity in vitro and in vivo. The objective of this study was to evaluate the peritoneal fluid levels of leptin in patients with endometriosis and idiopa…

2005

Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid.

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-005-4913-7

ObjectiveThe exact chemical composition of hydrosalpingeal fluid is unknown. The objective of this study was to characterize cytokines in hydrosalpingeal fluid (HSF) and examine their possible role in the embryo development.Study designHSF …

article 2005

Role of Endometriosis on Oocyte Quality and Fertility Outcome—An Evidence Based Review

·doi:10.1016/j.fertnstert.2005.07.1127

review 2005

Role of oxidative stress in female reproduction

Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-3-28

In a healthy body, ROS (reactive oxygen species) and antioxidants remain in balance. When the balance is disrupted towards an overabundance of ROS, oxidative stress (OS) occurs. OS influences the entire reproductive lifespan of a woman and …

article 2004

Effect of immunomodulatory agent − pentoxifylline on in vitro blastocyst development rate

·doi:10.1016/j.fertnstert.2004.07.839

letter 2004

Effect of tumor necrosis factor-α blocker (infliximab) on blastocyst development in vitro

·doi:10.1016/j.fertnstert.2003.12.019

Infliximab does not have any toxic effects on early cleaving embryos.

book-chapter 2004

Infertility

·doi:10.1007/978-0-306-48113-0_216

article 2004

Reversibility of tumor necrosis factor (TNF)-α induced toxic effects by infliximab in human spermatozoa

·doi:10.1016/j.fertnstert.2004.07.408

other 2004

Role of reactive oxygen species in gynecologic diseases

Reproductive medicine and biology ·doi:10.1111/j.1447-0578.2004.00068.x

Free radicals derived from molecular oxygen and nitrogen are highly reactive metabolites called reactive oxygen species (ROS). Cells continuously produce free radicals and ROS as part of the metabolic process. They are involved in the vario…

article 2004

TNF-alpha induced embryotoxicity and role of TNF-alpha blocker-infliximab on blastocyst development rate

·doi:10.1016/j.fertnstert.2004.07.413

article 2004

Toxicity of tumor necrosis factor (TNF)-α on human spermatozoa − Possible role in endometriosis associated infertility

·doi:10.1016/j.fertnstert.2004.07.407

article 2003

Differential contribution of reactive oxygen species and tumor necrosis factor-α to the peritoneal fluid-induced embryotoxicity in endometriosis patients

·doi:10.1016/s0015-0282(03)01517-6

article 2003

Effect of TNF-α blocker (Infliximab) on blastocyst development rate

·doi:10.1016/s0015-0282(03)01368-2

article 2003

Effects of peritoneal fluid from endometriosis patients on pre-implantation mouse embryo development and apoptosis

·doi:10.1016/s0015-0282(03)01516-4

article 2002

Assessment of leptin levels in the peritoneal fluid of patients with pelvic endometriosis and idiopathic infertility

·doi:10.1016/s0015-0282(02)04062-1

article 2002

Effect of ovarian involvement on peritoneal fluid cytokine levels in endometriosis patients

·doi:10.1016/s0015-0282(01)03039-4

article 2001

Local cytokine production and reactive oxygen species in the peritoneal fluid of endometriosis patients: prospective controlled study.

·doi:10.1016/s0015-0282(01)02206-3

article 2001

Systemic cytokine production in endometriosis patients: prospective controlled study.

·doi:10.1016/s0015-0282(01)02440-2

article 2001

The effect of follicular fluid reactive oxygen species on the outcome of in vitro fertilization.

International journal of fertility and women's medicine

OBJECTIVE: To examine the presence of reactive oxygen species (ROS) in the follicular fluid of women undergoing in vitro fertilization (IVF) and identify its role in pregnancy outcome. STUDY DESIGN: In this prospective study, ROS and total …

article 2000

Effect of Peritoneal Fluid of Infertile Mild/Minimal Endometriosis and Idiopathic Infertility Patients on In Vitro Mouse Embryo Development

·doi:10.1016/s0015-0282(00)01263-2