Rakesh Sharma — Endo Lab

observational 2007

Effect of ovarian involvement on peritoneal fl uid cytokine concentrations in endometriosis

Peritoneal fl uid cytokines are important for initiation and progression of endometriosis. The objective of this study was to compare a group of fi ve cytokines (interleukins IL-1β, IL-6, IL-8, IL-13 and tumour necrosis factor α; TNFα) in p…

2007

Endometriosis induced alterations in the mouse oocyte cytoskeleton

·doi:10.1016/j.fertnstert.2007.07.709

2007

Response of immature and mature mouse cytoskeleton to endometriosis – role of oxidative stress

·doi:10.1016/j.fertnstert.2007.07.697

2007

Sperm chromatin damage and its role in the pathogenesis of infertility in patients with endometriosis

·doi:10.1016/j.fertnstert.2007.07.1209

2005

Combined Effect of Oxidative Stress and Tumor Necrosis Factor-α on Mouse Oocyte Spindle Structure

·doi:10.1016/j.fertnstert.2005.07.488

lab-animal 2005

Effect of pentoxifylline in reducing oxidative stress-induced embryotoxicity

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-005-7202-6

PURPOSE: To 1) evaluate the embryotoxic effects of hydrogen peroxide on mouse embryo development and 2) examine if pentoxifylline can reverse hydrogen peroxide induced embryotoxicity. METHODS: Prospective in vitro study examining the effec…

2005

Effect of Tumor Necrosis Factor Induced Alterations in Microtubule and Chromosomal Alignment of Metaphase II Oocyte— Possible Role in Endometriosis Associated Infertility

·doi:10.1016/j.fertnstert.2005.07.1040

lab-animal 2005

Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro

Reproductive BioMedicine Online ·doi:10.1016/s1472-6483(10)61170-4

To evaluate the effect of peritoneal fluid (PF) on preimplantation mouse embryo development and apoptosis, PF was obtained from women presenting with (n = 7) and without endometriosis (n = 7). Mouse embryos were cultured to the blastocyst s…

nonrandomized-trial 2005

Infliximab may reverse the toxic effects induced by tumor necrosis factor alpha in human spermatozoa: an in vitro model

Fertility and sterility ·doi:10.1016/j.fertnstert.2004.11.068

OBJECTIVE: To examine the toxic effects of tumor necrosis factor alpha (TNF-alpha) on ejaculated spermatozoa and evaluate the ability of infliximab to reverse these effects. DESIGN: Prospective controlled study. SETTING: Cleveland Clinic …

2005

Modulation of Preimplantation Embryo Development and Apoptosis by Peritoneal Fluid From Patients With Endometriosis

·doi:10.1016/j.fertnstert.2005.07.1021

review 2005

Oxidative stress and its implications in female infertility - a clinician's perspective

Reproductive BioMedicine Online ·doi:10.1016/s1472-6483(10)61174-1

Reactive oxygen species (ROS) have a role in the modulation of gamete quality and gamete interaction. Generation of ROS is inherent in spermatozoa and contaminating leukocytes. ROS influence spermatozoa, oocytes, embryos and their environme…

observational 2005

Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients

Human Reproduction ·doi:10.1093/humrep/dei376

BACKGROUND: Leptin influences the proinflammatory immune responses and has angiogenic activity in vitro and in vivo. The objective of this study was to evaluate the peritoneal fluid levels of leptin in patients with endometriosis and idiopa…

lab-animal 2005

Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid

Journal of assisted reproduction and genetics ·doi:10.1007/s10815-005-4913-7

OBJECTIVE: The exact chemical composition of hydrosalpingeal fluid is unknown. The objective of this study was to characterize cytokines in hydrosalpingeal fluid (HSF) and examine their possible role in the embryo development. STUDY DESIGN…

2005

Role of Endometriosis on Oocyte Quality and Fertility Outcome—An Evidence Based Review

·doi:10.1016/j.fertnstert.2005.07.1127

review 2005

Role of oxidative stress in female reproduction

Reproductive biology and endocrinology : RB&E ·doi:10.1186/1477-7827-3-28

In a healthy body, ROS (reactive oxygen species) and antioxidants remain in balance. When the balance is disrupted towards an overabundance of ROS, oxidative stress (OS) occurs. OS influences the entire reproductive lifespan of a woman and …

2004

Effect of immunomodulatory agent − pentoxifylline on in vitro blastocyst development rate

·doi:10.1016/j.fertnstert.2004.07.839

lab-animal 2004

Effect of tumor necrosis factor-alpha blocker (infliximab) on blastocyst development in vitro

Fertility and sterility ·doi:10.1016/j.fertnstert.2003.12.019

Infliximab does not have any toxic effects on early cleaving embryos.

2004

Infertility

·doi:10.1007/978-0-306-48113-0_216

2004

Reversibility of tumor necrosis factor (TNF)-α induced toxic effects by infliximab in human spermatozoa

·doi:10.1016/j.fertnstert.2004.07.408

review 2004

Role of reactive oxygen species in gynecologic diseases

Reproductive medicine and biology ·doi:10.1111/j.1447-0578.2004.00068.x

Free radicals derived from molecular oxygen and nitrogen are highly reactive metabolites called reactive oxygen species (ROS). Cells continuously produce free radicals and ROS as part of the metabolic process. They are involved in the vario…

2004

TNF-alpha induced embryotoxicity and role of TNF-alpha blocker-infliximab on blastocyst development rate

·doi:10.1016/j.fertnstert.2004.07.413

2004

Toxicity of tumor necrosis factor (TNF)-α on human spermatozoa − Possible role in endometriosis associated infertility

·doi:10.1016/j.fertnstert.2004.07.407

2003

Differential contribution of reactive oxygen species and tumor necrosis factor-α to the peritoneal fluid-induced embryotoxicity in endometriosis patients

·doi:10.1016/s0015-0282(03)01517-6

2003

Effect of TNF-α blocker (Infliximab) on blastocyst development rate

·doi:10.1016/s0015-0282(03)01368-2

2003

Effects of peritoneal fluid from endometriosis patients on pre-implantation mouse embryo development and apoptosis

·doi:10.1016/s0015-0282(03)01516-4