Tong J

RESEARCH QUESTION: Does pyruvate carboxylase drive the progression of endometriosis, and, if so, what is the underlying mechanism? DESIGN: The expression of pyruvate carboxylase in clinical endometrial specimens was examined via immunohist…

Radon, a naturally occurring radioactive gas, is classified as a Group 1 carcinogen by the World Health Organization (WHO) and remains a significant environmental health hazard. Radon exposure is the second leading cause of lung cancer worl…

BACKGROUND: LY01021 is a novel oral small-molecule gonadotropin-releasing hormone (GnRH) receptor antagonist intended for the treatment of various sex hormone-dependent disorders. This study aimed to evaluate the safety, tolerability, pharm…

PURPOSE: The aim of this study was to summarize and analyze the incidence, underlying causes and related risk factors of misdiagnosis in patients with Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA) syndrome. METHODS: This is …

Ovarian cancer is a malignant tumor of ovary. It has the characteristics of difficult early diagnosis, poor late curative effect and high recurrence rate. It is the biggest disease that seriously threatens women's health. Single cell sequen…

BACKGROUND: Low-dose aspirin is one of the widely used adjuvants in assisted reproductive technologies with the hope of improving the live birth rate. However, the studies regarding its effects are conflicting. The study aimed to investigat…

The distinctive three-dimensional architecture, biological functionality, minimal immunogenicity, and inherent biodegradability of small intestinal submucosa extracellular matrix materials have attracted considerable interest and found wide…

Follicle development refers to the process in which the follicles in the ovary gradually develop from the primary stage to a mature state, and most primary follicles fail to develop normally, without forming a dense granular cell layer and …

Recurrent implantation failure (RIF) is an intrigue condition during in vitro fertilization (IVF) cycles or intracytoplasmic sperm injection (ICSI) treatments. The purpose of this retrospective study is to explore the value of next-generati…

BACKGROUND: Ewing's sarcoma is a common malignant bone tumor in children and young adults. Rarely, extra-skeletal soft tissues and visceral organs can also be the site of origin of Ewing's sarcoma. Primary pulmonary Ewing's sarcoma is an ex…

RATIONALE: Recurrent massive hemorrhagic ascites secondary to endometriosis is extremely rare in the medical literature. PATIENT CONCERNS: We report the case of a 24-year-old nulliparous woman presenting with severe abdominal distention, m…

OBJECTIVE: To describe the clinical characteristics of patients with Herlyn-Werner-Wunderlich syndrome (HWWS) and explore the relationship between an obstructive genital abnormality and pelvic endometriosis. DESIGN: Case series. SETTING: …

OBJECTIVE: To analyze the clinical characteristics of patients with Herlyn-Werner-Wunderlich (HWW) syndrome. METHODS: Seventy patients with a confirmed diagnosis of HWW syndrome admitted to the Peking Union Medical College Hospital between…

In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian canc…