Laisk T

No ORCID on file · 6 papers in corpus · active 2024-2026

Study types

  • other 2
  • meta-analysis 1
  • preprint 1

Condition tags

  • endometriosis 4
  • dysmenorrhea 1
  • irritable_bowel_syndrome 1
  • infertility 1
preprint 2026
Genetic analysis of female genital tract polyps implicates genome stability, estrogen signalling and shared susceptibility with proliferative gynaecological disorders
·doi:10.64898/2026.04.13.26350740

Abstract Female genital tract (FGT) polyps are common benign growths affecting up to half of all women. However, they carry malignant potential, and their genetic architecture remains poorly defined. We conducted a genome-wide association s…

meta-analysis 2025
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth
Human Reproduction ·doi:10.1093/humrep/deaf025

STUDY QUESTION: Can a large-scale genome-wide association study (GWAS) meta-analysis identify genomic risk loci and likely involved genes for female genital tract (FGT) polyps, provide insights into the biological mechanism underlying their…

2025
Hormonal contraceptive drug use trends in the Estonian Biobank
·doi:10.1101/2025.08.15.25333767

Importance Hormonal contraceptives (HCs) support reproductive goals and alleviate symptoms of gynaecological conditions for millions of women. Despite widespread use, individual long-term HC use trends, medication switching, and impact of …

other 2025
Interaction between genetic risk and comorbid conditions in endometriosis
HGG advances ·doi:10.1016/j.xhgg.2025.100456

Endometriosis is a complex disease, and many genetic and environmental risk factors contribute to disease risk. The genetic risk of endometriosis has been well characterized in genome-wide association studies. While few physiological risk f…

other 2024
Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum
medRxiv : the preprint server for health sciences ·doi:10.1101/2024.03.19.24304530

Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and 6…

2024
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity
·doi:10.21203/rs.3.rs-5487737/v1

Abstract While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal, fetal, and child out…