Samuel S.C. Yen

No ORCID on file · 8 papers in corpus · active 1989-2009

Study types

  • article 8

Condition tags

  • endometriosis 5
article 2009
Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix
·doi:10.1097/01.ogx.0000349783.36010.69

Peptide gonadotropin-releasing hormone (GnRH) antagonists are widely used to suppress the reproductive endocrine axis in women with endometriosis, fibroids, and other nonmalignant reproductive hormone-dependent disease states. Unlike treatm…

article 2008
Suppression of Gonadotropins and Estradiol in Premenopausal Women by Oral Administration of the Nonpeptide Gonadotropin-Releasing Hormone Antagonist Elagolix
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2008-1695

CONTEXT: Parenteral administration of peptide GnRH analogs is widely employed for treatment of endometriosis and fibroids and in assisted-reproductive therapy protocols. Elagolix is a novel, orally available nonpeptide GnRH antagonist. OBJE…

article 1995
Endometrial effects of long-term low-dose administration of RU486
Fertility and Sterility ·doi:10.1016/s0015-0282(16)57478-0

ObjectiveTo examine endometrial response to long-term low-does RU486 administration.DesignRetrospective controlled study of women with endometriosis treated for 6 months with 50 mg RU486 daily for 6 months. Controls consisted of women in th…

article 1993
Regression of Uterine Leiomyomata in Response to the Antiprogesterone RU 486
·doi:10.1097/00006254-199309000-00021

Uterine leiomyomata are steroid hormone-dependent tumors that are common in reproductive-age women. Some series have found leiomyomata in up to 20 per cent of women over 30 years of age. These tumors represent the most frequent indication f…

article 1992
Interruption of endometrial maturation without hormonal changes by an antiprogesterone during the first half of luteal phase of the menstrual cycle: a contraceptive potential
·doi:10.1016/s0015-0282(16)55200-5

ObjectiveTo examine hormonal and endometrial responses to intermittent low-dose RU486 administration in the luteal phase of the menstrual cycle.DesignProspective open trial in which subjects serve as their own controls.Patients/participants…

article 1991
Endocrine responses to long-term administration of the antiprogesterone RU486 in patients with pelvic endometriosis
Fertility and Sterility ·doi:10.1016/s0015-0282(16)54531-2

ObjectiveTo examine endocrine and clinical responses to long-term administration of RU486 in patients with endometriosis.DesignProspective open trial.SettingFaculty practice of the authors.Patients, participantsSix normally cycling women wi…

article 1990
Accelerated dissolution of luteal-endometrial integrity by the administration of antagonists of gonadotropin-releasing hormone and progesterone to late-luteal phase women
·doi:10.1016/s0015-0282(16)53936-3

Sequential blockade of gonadotropin-releasing hormone (GnRH) and progesterone (P) receptors by potent antagonists (Nal-Glu GnRH antagonist and RU486) was conducted in late-luteal phase women to develop a once-a-month birth control method by…

article 1989
Does prolonged dopaminergic blockade alter the LH pulsatile secretion in normal cycling and postmenopausal women?
·doi:10.1530/acta.0.1210147

To investigate effects of prolonged dopaminergic antagonism on LH pulsatile secretion, 22 normal cycling women (10 in the early follicular phase (days 3 and 4), 6 in the late follicular phase (days 10 to 13), 6 in the midluteal phase (days …