Donoghue LJ

No ORCID on file · 3 papers in corpus · active 2017-2020
2020
Peri- and Postpubertal Estrogen Exposures of Female Mice Optimize Uterine Responses Later in Life.
Endocrinology ·doi:10.1210/endocr/bqaa081

At birth, all female mice, including those that either lack estrogen receptor α (ERα-knockout) or that express mutated forms of ERα (AF2ERKI), have a hypoplastic uterus. However, uterine growth and development that normally accompany pubert…

2019
Negative elongation factor is essential for endometrial function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.201801752

Pausing of RNA polymerase II (Pol II) during early transcription, mediated by the negative elongation factor (NELF) complex, allows cells to coordinate and appropriately respond to signals by modulating the rate of transcriptional pause rel…

2017
Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation.
Scientific reports ·doi:10.1038/s41598-017-07728-1

Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal …