Wan R

No ORCID on file · 4 papers in corpus · active 2017-2026
2026
IL18 Works Like a Two-Side Coin in Acute Pancreatitis.
International journal of general medicine ·doi:10.2147/ijgm.s606433

PurposeAcute pancreatitis is a common disease with limited supportive treatments. Finding effective biomarkers is of great significance for early diagnosis and therapy, as well as to achieve better prognosis.Materials and methodsThe core ge…

2021
Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians.
Genome medicine ·doi:10.1186/s13073-021-00831-z

BackgroundThe clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear.MethodsWe used data from Biobank Japan (n = 70,657-128,305) and develo…

2020
Myeloid-specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage.
British journal of pharmacology ·doi:10.1111/bph.15026

Background and purposeMacrophage infiltration and activation is a critical step during acute pancreatitis (AP). We have shown that pancreas-specific D2 receptor signalling protects against AP severity. As it is unclear to what extent myeloi…

2017
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway.
British journal of pharmacology ·doi:10.1111/bph.14057

Background and purposeDopamine has multiple anti-inflammatory effects, but its role and molecular mechanism in acute pancreatitis (AP) are unclear. We investigated the role of dopamine signalling in the inflammatory response in AP.Experimen…