Gede N

No ORCID on file · 3 papers in corpus · active 2022-2023
2023
Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] ·doi:10.1016/j.pan.2023.05.013

Chymotrypsin C (CTRC) is a digestive serine protease produced by the pancreas that regulates intrapancreatic trypsin activity and provides a defensive mechanism against chronic pancreatitis (CP). CTRC exerts its protective effect by promoti…

2022
Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis.
PloS one ·doi:10.1371/journal.pone.0276397

IntroductionCystic fibrosis transmembrane conductance regulator (CFTR) plays a central role in pancreatic ductal fluid secretion by mediating Cl- and HCO3- ion transport across the apical membrane. Severe CFTR mutations that diminish chlori…

2022
Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis.
PloS one ·doi:10.1371/journal.pone.0268859

The digestive protease chymotrypsin C (CTRC) protects the pancreas against pancreatitis by degrading potentially harmful trypsinogen. Loss-of-function genetic variants in CTRC increase risk for chronic pancreatitis (CP) with variable effect…