Koulakmanidis AM

No ORCID on file · 13 papers in corpus · active 2025-2026

Study types

  • review 5

Condition tags

  • endometriosis 3
  • infertility 3
review 2026
International journal of molecular sciences ·doi:10.3390/ijms27104559

Infertility and ovarian ageing are increasingly acknowledged as illnesses affected not just by endocrine decline but also by chronic inflammatory stress and mitochondrial dysfunction in the reproductive milieu. The cGAS-STING signalling pat…

2026
International journal of molecular sciences ·doi:10.3390/ijms27114710

Oxidative stress is a fundamental mechanism that impacts reproductive function by altering gamete quality, fertilisation, and the initial development of embryos. Excessive reactive oxygen species lead to the oxidation of polyunsaturated fat…

2026
International journal of molecular sciences ·doi:10.3390/ijms27020950

The functional deterioration of granulosa cells (GCs), essential for follicular growth, steroidogenesis, and oocyte competence, indicates ovarian aging and reduced fertility. An expanding corpus of research indicates that oxidative stress i…

2026
Journal of clinical medicine ·doi:10.3390/jcm15114089

Aim: The purpose of this study was to investigate the safety, efficacy, and clinical outcomes of the vaginal natural orifice transluminal endoscopic surgery (vNOTES) technique in patients suffering from gynecological cancer. Methods: A syst…

review 2025
International journal of molecular sciences ·doi:10.3390/ijms26136377

The success of in vitro fertilization (IVF) and female reproductive capacity are significantly determined by oocyte quality. Increasing data highlights the significance of oxidative stress-a state of imbalance between reactive oxygen specie…

2025
International journal of molecular sciences ·doi:10.3390/ijms26115363

Exosomal microRNAs (ex-miRs), encapsulated in extracellular vesicles (EVs), play a vital role in facilitating paracrine communication among granulosa cells (GCs), cumulus cells (CCs), and the oocyte inside follicular fluid (FF). These small…

review 2025
International journal of molecular sciences ·doi:10.3390/ijms262110381

Ferroptosis is a novel kind of regulated cell death that occurs when redox equilibrium is disrupted, leading to iron-dependent lipid peroxidation. Ferroptosis is defined by the buildup of deleterious lipid hydroperoxides, the inactivation o…

2025
Biomedicines ·doi:10.3390/biomedicines13082044

Numerous infants have been conceived by in vitro fertilization (IVF) and other assisted reproductive technologies (ART). Increasing evidence indicates that these approaches induce minor alterations in molecules during the initial phases of …

review 2025
Current issues in molecular biology ·doi:10.3390/cimb47110956

Endometriosis impairs fertility by interfering with ovarian function, embryonic development, and endometrial receptivity. Extracellular vesicles (EVs) are recognised as non-invasive biomarkers that may indicate biological processes based on…

review 2025
International journal of molecular sciences ·doi:10.3390/ijms262311359

The reduction in oocyte competence and ovarian reserve coincides with reproductive ageing; nevertheless, the molecular mechanisms underlying this phenomenon remain poorly understood. Our testable mechanistic hypothesis is that the oxidative…

2025
Genes ·doi:10.3390/genes16121400

Background/objectivesApproximately 50% of infertility cases are attributable to male factors; yet conventional semen examination can not identify the molecular abnormalities that hinder sperm functionality. Extracellular vesicles (EVs) deri…

2025
Cells ·doi:10.3390/cells14110787

Background: MicroRNAs (miRNAs) in follicular fluid (FF) are being recognized as important regulators of ovarian function and biomarkers of reproductive success. This systematic analysis investigates FF-derived miRNAs and their relationship …

2025
Journal of clinical medicine ·doi:10.3390/jcm14165713

Aim: This study was conducted to determine the feasibility, safety, and clinical outcomes of the vaginal natural-orifice transluminal endoscopic surgery (vNOTES) approach in gynecology for obese patients. Methods: PubMed, Cochrane Library, …