Borsook D

Endometriosis is a highly prevalent and often painful gynecological condition that can emerge in adolescence and can be experienced throughout a person's lifetime. This cross-sectional investigation performed structural brain imaging and a …

SignificanceQuantitative measurement of perisurgical brain function may provide insights into the processes contributing to acute and chronic postsurgical pain.AimWe evaluate the hemodynamic changes in the prefrontal cortex (medial frontopo…

BACKGROUND: Endometriosis is the leading cause of chronic pelvic pain. Alterations in brain functional connectivity have been reported in adult women with endometriosis-associated pain (EAP), however, it is still unknown if similar patterns…

Chronic pain and depression are two frequently co-occurring and debilitating conditions. Even though the former is treated as a physical affliction, and the latter as a mental illness, both disorders closely share neural substrates. Here, w…

Claire E Lunde, 1– 3,* Edina Szabo, 1, 4,* Scott A Holmes, 1, 4 David Borsook, 1, 4 Christine B Sieberg 1, 2, 5 1Center for Pain and the Brain (P.A.I.N. Group), Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children…

BACKGROUND AND OBJECTIVE: Endometriosis, affecting approximately 176 million adults and adolescents worldwide, is a debilitating condition in which uterine tissue grows outside the uterus. The condition costs the US economy approximately $7…

Endometriosis, a condition in which uterine tissue grows outside the uterus, is a debilitating disease, affecting millions of women and costing the United States approximately $78 billion annually in pain- related disability. It is also the…

BackgroundThe experience of persistent pain in multiple locations is common in youth. Based on current literature, youth with multiple pain sites (MPS) are at risk of experiencing poorer emotional outcomes and a spread of symptoms into late…

Moderate to severe chronic pain is a problem for 1.7 million children, costing $19.5 billion dollars annually in the United States alone. Risk-stratified care is known to improve outcomes in adults with chronic pain. However, no tool exists…

This review describes some of the recent developments in imaging aspects of pain in the periphery. It is now possible to image nerves in the cornea non-invasively, to image receptor level expression and inflammatory processes in injured tis…

Evaluating external and internal stimuli is critical to survival. Potentially tissue-damaging conditions generate sensory experiences that the organism must respond to in an appropriate, adaptive manner (e.g., withdrawal from the noxious st…