Samuel Leung

ORCID: 0000-0003-0138-7254 · 7 papers in corpus · active 2014-2025

Study types

  • preprint 3
  • article 2
  • other 2

Condition tags

  • endometriosis 4
  • mesh:D004715 1
other 2025
Cystathionine gamma-lyase-mediated hypoxia inducible factor 1-alpha expression drives clear cell ovarian cancer progression
The Journal of Pathology ·doi:10.1002/path.6433

Clear cell ovarian cancer (CCOC) is the second most common ovarian cancer subtype, accounting for 5%-11% of ovarian cancers in North America. Late-stage CCOC is associated with a worse prognosis compared to other ovarian cancer histotypes, …

preprint 2023
Supplementary Figure S5 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
·doi:10.1158/0008-5472.22403919.v1

Supplementary Figure S5. Significance of STAT1-MYC activity in tumorigenesis.

preprint 2023
Supplementary Figure S5 from STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer
·doi:10.1158/0008-5472.22403919

Supplementary Figure S5. Significance of STAT1-MYC activity in tumorigenesis.

preprint 2021
Prognostic and Immunological Significance of ARID1A Status in Endometriosis-Associated Ovarian Carcinoma
·doi:10.1101/2021.09.16.21262993

Abstract ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumor suppressor role, and is considered prognostic in several malignancies. However, in ovarian carcinomas there are contradictory repo…

article 2021
Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8 + TIL infiltration, and provides no independent prognostic value in endometriosis‐associated ovarian carcinomas
The Journal of Pathology ·doi:10.1002/path.5849

Abstract ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumour suppressor role, and is considered prognostic in several malignancies. However, in ovarian carcinomas there are contradictory rep…

article 2020
Abstract B09: Single-cell RNA sequencing of normal endometrial organoids uncovers novel cell-type markers for prognostication of primary tumor samples
·doi:10.1158/1557-3265.ovca19-b09

Abstract Endometrial epithelium gives rise to both endometrial and ovarian cancers (of clear-cell and endometrioid subtypes), the latter arising from ectopic endometrium (endometriosis). Endometrial epithelium comprises mainly secretory cel…

other 2014
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
BMC cancer ·doi:10.1186/1471-2407-14-120

BACKGROUND: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and freq…