Lee J Middleton

No ORCID on file · 5 papers in corpus · active 2017-2024

Study types

  • article 3
  • other 1
  • rct 1

Condition tags

  • mesh:D004715 3
  • endometriosis 3
  • mesh:D017699 2
  • chronic_pelvic_pain 1
  • endometrioma 1
  • adenomyosis 1
article 2024
Long acting progestogens versus combined oral contraceptive pill for preventing recurrence of endometriosis related pain: the PRE-EMPT pragmatic, parallel group, open label, randomised controlled trial
BMJ (Clinical research ed.) ·doi:10.1136/bmj-2023-079006

Abstract Objectives To evaluate the clinical effectiveness of long acting progestogens compared with the combined oral contraceptive pill in preventing recurrence of endometriosis related pain. Design The PRE-EMPT (preventing recurrence of …

other 2023
Ulipristal acetate versus levonorgestrel-releasing intrauterine system for heavy menstrual bleeding (UCON): a randomised controlled phase III trial
EClinicalMedicine ·doi:10.1016/j.eclinm.2023.101995

BACKGROUND: Heavy menstrual bleeding affects one in four women and negatively impacts quality of life. Ulipristal acetate is prescribed to treat symptoms associated with uterine fibroids. We compared the effectiveness of ulipristal acetate …

article 2021
Uterine artery embolization or myomectomy for women with uterine fibroids: Four-year follow-up of a randomised controlled trial
European journal of obstetrics & gynecology and reproductive biology: X ·doi:10.1016/j.eurox.2021.100139

OBJECTIVE: To examine the quality of life experienced by women with symptomatic uterine fibroids who had been treated with UAE in comparison to myomectomy. We report the four-year follow-up of the FEMME randomised trial. Two-year follow-up …

article 2018
MRI versus laparoscopy to diagnose the main causes of chronic pelvic pain in women: a test-accuracy study and economic evaluation
Health technology assessment (Winchester, England) ·doi:10.3310/hta22400

Background Chronic pelvic pain (CPP) symptoms in women are variable and non-specific; establishing a differential diagnosis can be hard. A diagnostic laparoscopy is often performed, although a prior magnetic resonance imaging (MRI) scan may…

rct 2017
Preventing recurrence of endometriosis by means of long-acting progestogen therapy (PRE-EMPT): report of an internal pilot, multi-arm, randomised controlled trial incorporating flexible entry design and adaption of design based on feasibility of recruitment
Trials ·doi:10.1186/s13063-017-1864-0

BACKGROUND: Endometriosis is associated with the growth of endometrium in ectopic sites mainly within the pelvis. This results in inflammation and scarring, causing pain and impaired quality of life. Endometriotic lesions can be excised or …