Abigail Ruiz

High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, reported to be elevated in h…

UnlabelledLysyl oxidases (LOXs) are enzymes involved in collagen deposition, extracellular membrane remodeling, and invasive/metastatic potential. Previous studies reveal an association of LOXs and endometriosis. We aimed to identify the me…

Endometriosis defined as the presence of endometrial stroma and glands outside the uterus, is associated with chronic pain, inflammation, and increased levels of chemokines. We reported high CXCR4 mRNA levels in endometriotic lesions in a r…

Endometriosis is defined as the presence of the endometrial tissue outside of the uterine cavity, primarily on the pelvic peritoneum, and ovaries. The main symptoms are chronic pelvic pain, pain during intercourse, and infertility. High CXC…

Epigenetic mechanisms have been ascribed important roles in endometriosis. Covalent histone modifications at lysine residues have been shown to regulate gene expression and thus contribute to pathological states in many diseases. In endomet…

Endometriosis is a gynecological disease that affects 1 in 10 women during their reproductive years, cause incapacitating pelvic pain and infertility. Endometriosis is characterized by the growth of endometrial tissue outside the uterine ca…

This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like pr…

Endometriosis is considered a multifactorial disease influenced by genetic predisposition, deficient immune system and environmental factors. The most common symptoms are chronic pelvic pain and infertility. The pathophysiological mechanism…

Endometriosis is associated with activation of local and systemic inflammatory mechanisms, including increased levels of chemokines and other proinflammatory cytokines. We have previously reported increased gene expression of chemokine rece…

Endometriosis is a gynecological disease characterized by the presence of stroma and epithelial cells outside the uterine cavity, causing pain and infertility. This disease is estrogen-dependent and is associated with the activation of infl…

The objective of this study was to assess the burden of endometriosis by obtaining patient-reported outcome data describing the experience of living with this disease. Survey data from 107 women with self-reported, surgically diagnosed endo…

Endometriosis is a common, incurable gynecologic disease of unknown etiology, which causes incapacitating pain during menses and infertility. There are no specific non-invasive diagnostic tests for endometriosis, therefore diagnosis is curr…