Yoshihara K

No ORCID on file · 11 papers in corpus · active 2018-2026

Study types

  • article 5
  • case-report 2

Condition tags

  • endometriosis 6
  • dysmenorrhea 2
  • chronic_pelvic_pain 1
  • infertility 1
  • adenomyosis 1
2026
Title: AI-based quantification of tumor-infiltrating lymphocytes with integrative transcriptomics in ovarian clear cell carcinoma: JGOG3025-TR1/A1 study.
Cancer immunology, immunotherapy : CII ·doi:10.1007/s00262-026-04324-z

Transcriptomic classification methods have been proposed for ovarian clear cell carcinoma. However, their clinical significance and association with pathologically evaluated tumor-infiltrating lymphocytes (TILs) remain unclear. We establish…

case-report 2025
A case of deep endometriosis with cyst formation as a differential diagnosis of rectal duplication cyst in the presacral space
Clinical journal of gastroenterology ·doi:10.1007/s12328-025-02100-7

Cysts occurring in the presacral space may become malignant and therefore require surgical removal. A wide variety of cystic lesions can occur in the presacral space, such as tailgut cysts, dermoid cysts, and duplication cysts. However, dee…

case-report 2025
A live birth after bilateral salpingo-oophorectomy for seromucinous borderline ovarian tumor
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.16323

Borderline ovarian tumors primarily affect younger women and are associated with favorable prognosis, making fertility-sparing surgery a viable option. However, owing to recurrence and malignant transformation risks, careful monitoring is r…

2024
Drug Delivery Strategies for Age-Related Diseases.
International journal of molecular sciences ·doi:10.3390/ijms25168693

Drug delivery systems (DDSs) enable the controlled release of drugs in the body. DDSs have attracted increasing attention for the treatment of various disorders, including cancer, inflammatory diseases, and age-related diseases. With recent…

article 2022
Quality of Life in Japanese Patients with Dysmenorrhea or Endometriosis-Associated Pelvic Pain Treated with Extended Regimen Ethinylestradiol/Drospirenone in a Real-World Setting: A Prospective Observational Study
Advances in therapy ·doi:10.1007/s12325-022-02301-3

INTRODUCTION: Dysmenorrhea and endometriosis are common gynecologic disorders among women of reproductive age that significantly impact health-related quality of life (HRQL) as well as productivity. Although there are treatment options list…

2022
Quality of Life of Japanese Dysmenorrhea/Heavy Menstrual Bleeding Patients Treated with Levonorgestrel Intrauterine Delivery System in a Real-World Setting.
Advances in therapy ·doi:10.1007/s12325-022-02205-2

IntroductionThe present study collected 1-year follow-up patient-reported outcome data from Japanese women with dysmenorrhea and/or heavy menstrual bleeding (HMB) who underwent insertion of the levonorgestrel-releasing intrauterine system (…

article 2021
Three-dimensional understanding of the morphological complexity of the human uterine endometrium
iScience ·doi:10.1016/j.isci.2021.102258

The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these glands have complicated winding and branching patterns. To construct a large picture of the endometrial gland structure, we …

article 2020
ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis
Scientific reports ·doi:10.1038/s41598-020-71273-7

ARID1A loss-of-function mutation accompanied by a loss of ARID1A protein expression is considered one of the most important driver events in endometriosis-associated ovarian cancer. Although our recent genomic study clarified that ARID1A lo…

article 2020
Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality
Human genetics ·doi:10.1007/s00439-020-02223-6

Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing g…

2019
Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer.
Gynecologic Oncology ·doi:10.1016/j.ygyno.2019.08.007

ObjectiveTo examine the association between ovarian conservation and oncologic outcome in surgically-treated young women with early-stage, low-grade endometrial cancer.MethodsThis multicenter retrospective study examined women aged <50 with…

article 2018
Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium
Cell reports ·doi:10.1016/j.celrep.2018.07.037

Endometriosis is characterized by ectopic endometrial-like epithelium and stroma, of which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic and 82 normal uterine endometrial epithelium samples …