Seiya Sato

ORCID: 0000-0002-5058-9189 · 4 papers in corpus
2023
Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation.
Cancer science ·doi:10.1111/cas.15767

Recent studies reported the presence of oncogenic mutations in normal endometrial glands, but the biological significance remains unclear. The present study investigated the status of KRAS/PIK3CA driver mutations in normal endometrial gland…

article 2021
Establishment of a Novel In Vitro Model of Endometriosis with Oncogenic KRAS and PIK3CA Mutations for Understanding the Underlying Biology and Molecular Pathogenesis
Cancers ·doi:10.3390/cancers13133174

Endometriosis-harboring cancer-associated somatic mutations of PIK3CA and KRAS provides new opportunities for studying the multistep processes responsible for the functional and molecular changes in this disease. We aimed to establish a nov…

article 2021
Whole-Exome Sequencing of Rare Site Endometriosis-Associated Cancer
Diseases (Basel, Switzerland) ·doi:10.3390/diseases9010014

Malignant transformation of extraovarian endometriosis is rare, with the carcinogenesis mechanism unclear. To clarify the actionable variants of rare-site endometriosis-associated cancer (RSEAC), we performed whole-exome sequencing for the …

review 2020
Cancer-associated mutations in normal human endometrium: Surprise or expected?
Cancer science ·doi:10.1111/cas.14571

The human endometrium is an essential component in human reproduction that has the unique characteristic of undergoing cyclic regeneration during each menstrual cycle. Vigorous regeneration after shedding may be sustained by stem/progenitor…