Chen X

BACKGROUND: The adnexal region in females presents complex imaging due to the menstrual cycle. Accurate diagnosis is crucial for effective tumor treatment. This study aims to assess the clinical utility of abnormal adnexal uptake on 68Ga-FA…

OBJECTIVE: To investigate the clinical efficacy and potential mechanisms of Traditional Chinese Medicine (TCM) combined with High-Intensity Focused Ultrasound (HIFU) in the treatment of adenomyosis, providing evidence-based support for opti…

The human endometrial immune landscape is critical for homeostasis and pregnancy success, yet its dynamic remodeling across the menstrual cycle and in pathology remains poorly characterized. Here, we construct a comprehensive immune cell at…

Abstract Objective To identify risk factors for postoperative pelvic–abdominal infection after total laparoscopic hysterectomy in patients with benign gynecological diseases and to develop and validate a clinically applicable prediction m…

Endometrial cancer (EC) incidence is rising, yet current diagnostics lack precision and scalability. We develop an artificial intelligence (AI)-based platform integrating multi-biofluid omics and clinical data for EC stratification. Using t…

Pelvic inflammatory disease (PID), a prevalent gynecological ailment compromising women's health, demonstrates established risk mitigation from dietary trace minerals. However, iron's role in PID pathogenesis remains unestablished. The Nati…

BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of reproductive age, and accumulating evidence suggests that gut microbiota dysbiosis plays an important role in its pathogenesis, although mic…

BACKGROUND: Women with gynecologic malignancies may require intensive care unit (ICU) admission for postoperative complications, infection, organ dysfunction, treatment-related toxicity, or advanced cancer. Multicohort ICU outcome data for …

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a rare aggressive, and chemo-resistant subtype of epithelial ovarian cancer. Current limitations in precisely characterizing its molecular features have resulted in restricted availability …

Female reproductive disorders widely affect women of reproductive age, yet their shared genetic basis remains incompletely understood, limiting insight into the biological mechanisms linking these conditions. Here, we analyse genetic data f…

Early detection of asymptomatic ovarian cancer (asym-OC) remains a critical challenge, the failure of which underlies its high mortality. Performing serum peptidomic profiling of 843 participants in the cohort SOCFCP, we distill 1,081 initi…

BACKGROUND: The follicular-phase long GnRHa protocol is a common protocol in COH. This study mainly analyzed the recovery of FSH levels on the day of Gn initiation compared with basal FSH levels on the day of downregulation and studied the …

OBJECTIVE: The aim of this study was to compare the therapeutic efficacy of integrating virtual reality technology with conventional pelvic floor rehabilitation therapy versus conventional therapy alone in postpartum women with myofascial p…

OBJECTIVE: To identify risk factors for recurrence after hysteroscopic endometrial polypectomy, with particular emphasis on postoperative pathological features (endometrial hyperplastic changes) and potential protective role of medical ther…

BACKGROUND: Endometriosis (EMs) is a chronic enigmatic gynecological disorder which pathogenesis have not been fully elucidated. Exosomes have been proven to participate in endometriosis. However, the role of exosomes in the pathogenesis of…

BACKGROUND: Syndrome differentiation in Traditional Chinese Medicine (TCM) is pivotal to clinical practice and dictates the efficacy of medicinal treatments. However, precision diagnostic models for TCM syndromes, constructed from biomarker…

Endometriosis (EM) is a common chronic gynecological disorder in women of reproductive age, yet its pathogenesis remains unclear, and current therapeutic options are limited by significant side effects. Endometriosis itself increases the ri…

OBJECTIVES: This study aims to evaluate the safety and efficacy of ovarian vein embolization combined with polidocanol sclerotherapy for Venous-origin chronic pelvic pain (VO-CPP) and to elucidate potential risk factors affecting prognosis.…

Endometriosis (EMs) is a common estrogen-dependent inflammatory disease characterized by pelvic pain and infertility. Despite its substantial clinical burden, its etiology and pathogenesis remain incompletely resolved, and current managemen…

Uterine aging impairs fertility and reproductive health, but the underlying pathogenic mechanisms and effective treatment strategies remain elusive. Defective endometrial decidualization and implantation failure are hallmarks of uterine agi…

BACKGROUND: Endometriosis (EMs) is a chronic inflammatory disease characterized by tumor-like growth behavior and limited therapeutic options. Increasing evidence suggests that gut microbiota may contribute to EMs progression by promoting c…

BACKGROUND: The specific gut microbial signatures and their correlation with immune-inflammatory markers in infertile women with endometriosis remain underexplored.To investigate the differences in gut microbiota and their associations with…

BACKGROUND: Endometrial intrauterine adhesions (IUA) arise due to comprised regenerative capacity of endometrium and aberrant fibrotic processes. These adhesions significantly affect fertility by impeding embryo implantation, sustaining pre…

Endometriosis is a common gynecological disorder in which inflammatory and immune responses play a crucial role in its development and progression. This study aimed to identify potential inflammation-related biomarkers for the diagnosis and…