Mardon HJ

No ORCID on file · 11 papers in corpus · active 1996-2010

Study types

  • article 6
  • other 1

Condition tags

  • endometriosis 7
  • infertility 2
2010
Human endometrial stromal cell rho GTPases have opposing roles in regulating focal adhesion turnover and embryo invasion in vitro.
Biology of reproduction ·doi:10.1095/biolreprod.109.080630

Implantation of the embryo into the uterine compartment is a multistep event involving attachment of the embryo to the endometrial epithelia, followed by invasion of the embryo through the endometrial stroma. RHOA, RAC1, and CDC42 are membe…

article 2007
Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression
Human Reproduction ·doi:10.1093/humrep/dem262

BACKGROUND: Endometriosis, classified as the presence of endometrial cells in ectopic sites, is a debilitating disease causing pain and infertility in approximately 10% of women of reproductive age. It is associated with the aberrant expres…

article 2006
Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity
Fertility and sterility ·doi:10.1016/j.fertnstert.2005.08.046

ObjectiveTo evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis.DesignExperimental study using phase contrast microscopy, im…

2005
The production of interleukin-11 and decidualization are compromised in endometrial stromal cells derived from patients with infertility.
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2004-0868

IL-11 signaling is critical for decidualization of the endometrial stroma in early pregnancy in the mouse. In this study, we investigate the function of IL-11 signaling in cAMP-induced decidualization of human endometrial stromal cells. We …

2003
Functional characterization of W147A: a high-affinity interleukin-11 antagonist.
Endocrinology ·doi:10.1210/en.2002-0144

IL-11 is a member of the gp130 family of cytokines, which signal via assembly of multisubunit receptor complexes containing at least one molecule of the transmembrane signaling receptor gp130. IL-11 forms a high-affinity complex, thereby in…

2002
The characteristics of integrins expression in decidualized human endometrial stromal cell induced by 8-Br-cAMP in in vitro.
Experimental & molecular medicine ·doi:10.1038/emm.2002.28

Integrins are heterodimeric glycoproteins that have been found to undergo dynamic temporal and spatial changes in the endometrium during the menstrual cycle and in early pregnancy. Specificity of integrins is known to be different in human …

article 2001
Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1 and CYP1A1
Molecular human reproduction ·doi:10.1093/molehr/7.11.1073

An association between endometriosis and the glutathione S-transferase (GST) M1 null mutation has been reported in French and Slavic populations. We aimed to replicate this association of endometriosis in a UK population, and to test for as…

article 1999
Absence of a relationship between endometriosis and the N314D polymorphism of galactose-1-phosphate uridyl transferase in a UK population
Molecular human reproduction ·doi:10.1093/molehr/5.10.990

An association between the N314D polymorphism of galactose-1-phosphate uridyl transferase and endometriosis has recently been reported in a North American population. To determine whether such an association exists in the UK population, we …

article 1999
Tenascin is differentially expressed in endometrium and endometriosis
The Journal of Pathology ·doi:10.1002/(sici)1096-9896(199901)187:2<242::aid-path221>3.0.co;2-t

Endometriosis is characterized by the presence of functional endometrial tissue outside the uterine cavity, most commonly on the ovary and peritoneum. The aetiology of endometriosis is not understood, although the adhesion of endometrial ce…

article 1997
Endometriosis in monozygotic twins
Fertility and Sterility ·doi:10.1016/s0015-0282(97)00359-2

ObjectiveTo describe the occurrence of endometriosis in monozygotic twins.DesignPostal questionnaire plus confirmation of disease status.SettingTwins were recruited via the American Endometriosis Association and the National Endometriosis S…

other 1996
Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis
The Journal of Pathology ·doi:10.1002/(SICI)1096-9896(199610)180:2<181::AID-PATH620>3.0.CO;2-I

The expression of integrin subunits has been investigated in the stroma and epithelium of eutopic and ectopic endometrial tissues, using immunohistochemistry and fluorescently activated cell-sorting techniques. Integrin subunits exhibited t…