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Uterine leiomyoma (UL) is a hormone-dependent benign tumor of uterus. Social significance of UL is stipulated by its high rate among fertile females. Scarce data exist about the impact of cytokines in UL progression. Th1/Th2 paradigm is one…
AIMS: Estrogen-dependent hyperplasia of myo- and endometrium manifests as uterine leiomyoma or adenomyosis. We studied possible associations between common polymorphisms of matrix metalloproteinase (MMP) genes and clinical features of uteri…
Carriage of hyperactive alleles of matrix metalloproteinase-1 (MMP-1) gene is associated with enhanced growth of various neoplasias in humans. When studying the frequency of promoter variants of MMP -1 and -3 genes in 170 patients with uter…
Carriage of hyperactive alleles of matrix metalloproteinase-1 (MMP-1) gene is associated with enhanced growth of various neoplasias in humans. When studying the frequency of promoter variants of MMP -1 and -3 genes in 170 patients with uter…