Xin Wang

OBJECTIVE: To investigate the relationship between serum progesterone (P) on the day of embryo transfer (ET) and pregnancy outcomes in patients classified as POSEIDON Group 1. METHODS: This retrospective cohort study was conducted at the R…

OBJECTIVE: To investigate the association between the dynamic trajectories of urinary human chorionic gonadotropin (hCG) and the risk of early miscarriage after embryo transfer. METHODS: In this prospective cohort study conducted in Hebei …

OBJECTIVE: Adenomyosis (AM) is a complex disease with poorly understood pathogenesis and considerable clinical phenotypic heterogeneity. Cluster analysis of coexisting diseases may help identify distinct clinical subtypes of AM and explore …

OBJECTIVE: This study aims to evaluate and compare the clinical effectiveness of endovascular reintervention vs conservative medical therapy in patients with persistent or recurrent venous-origin chronic pelvic pain (CPP) after initial endo…

目的 探讨桂枝-重楼有效成分联用抑制子宫腺肌病（AM）进展的相关分子机制。 方法 利用梯度浓度的重楼皂苷（PP）I、II、VII（PPI、PPII、PPVII）及桂枝有效成分反式肉桂醛（TCA）分别处理子宫腺肌病原代细胞（AMDC），通过CCK-8法检测药物对AMDC活力的影响；正交实验筛选PPII与TCA最佳配比（简称PT），Transwell检测细胞侵袭、迁移能力；网络药理学筛选出PT治疗AM的关键通路；利用梯度浓度的PT腹腔注射ICR小鼠30 d，评价药物的安全性…

Varicocele-induced decline in sperm quality is a common cause of male infertility. While varicocelectomy improves semen parameters, the mechanisms remain unclear. Recent studies suggested that small noncoding RNAs (sncRNAs) in sperm play a …

OBJECTIVE: To explore factors related to dysmenorrhea in adenomyosis and construct a risk prediction model. METHODS: A cross-sectional survey involving 1636 adenomyosis patients from 37 hospitals nationwide (November 2019-February 2022) wa…

Diabetic kidney disease (DKD) is recognized as one of the leading causes of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide, representing a rapidly growing global public health concern. Despite significant advance…

Ovarian clear cell carcinoma (OCCC) represents a rare and aggressive subtype of epithelial ovarian cancer with distinctive clinical and molecular characteristics. However, the identification, origin, and molecular features of the malignant …

Immune escape is a phenomenon in which tumor cells or infections evade detection and clearance by the host immune system in various ways. During an antitumor immune response, cells increase the concentration of pentameric stalk, which enhan…

OBJECTIVE: This study aimed to explore the differences in symptom clusters of adenomyosis (AM) patients across spatial, temporal, and age-stratified dimensions based on the theory of "Treatment in Accordance with Three Categories of Etiolog…

BACKGROUND: Ferroptosis is a newly characterized iron-dependent form of regulated cell death. In adenomyosis (AM), ectopic endometrial lesions exhibit resistance to ferroptosis, which contributes to disease progression and recurrence. Tongm…

Background/Objectives: Aromatase plays a crucial role in the conversion of androgens to oestrogens and is often overexpressed in hormone-dependent tumours, particularly breast cancer. [18F]BIBD-071, which has excellent binding affinity for …

Abstract Objective To explore factors related to dysmenorrhea in adenomyosis and construct a risk prediction model. Methods A cross-sectional survey involving 1636 adenomyosis patients from 37 hospitals nationwide (November 2019 - Februa…

OBJECTIVE: To assess the efficacy and safety of Sanjie Analgesic Capsule (SAC) in Chinese patients with endometriosis-associated pain. METHODS: This was a multicenter, randomized, double-blind, placebo-controlled trial conducted at 15 cent…

BACKGROUND: Endometriosis is a common gynecological disease that affects approximately 5 %∼10 % of reproductive-aged women. Zinc (Zn), selenium (Se), copper (Cu), cobalt (Co) and molybdenum (Mo) are essential trace elements and are very imp…

BACKGROUND AND AIMS: Hepatic fibrosis (HF) is a critical step in the progression of hepatocellular carcinoma (HCC). Gene associated with retinoid-IFN-induced mortality 19 (GRIM19), an essential component of mitochondrial respiratory chain c…

BACKGROUND: The active ingredients of the Chinese medical herb Paris polyphylla, P. polyphylla ethanol extract (PPE) and polyphyllin I (PPI), potentially inhibit epithelial-mesenchymal transition (EMT) in tumors. However, the roles of these…

Macroautophagy, commonly referred to as autophagy, is an essential cytoprotective mechanism that plays a significant role in cellular homeostasis. It has emerged as a promising target for drug development aimed at treating various cancers a…

PURPOSE: With urbanization and industrialization process accelerated, humans are exposed more and more trace elements. This study aimed to explore the potential associations of trace elements with the outcomes of in vitro fertilization embr…

BACKGROUND & AIMS: Loss of AT-rich interactive domain-containing protein 1A (ARID1A) fosters acinar-to-ductal metaplasia (ADM) and pancreatic carcinogenesis by down-regulating transcription programs controlling acinar cell identity. However…

BACKGROUND: Aldo-keto reductase 1B10 (AKR1B10) is a secretory protein that is upregulated in breast cancer. OBJECTIVE: This case-controlled pilot study evaluated the serum level of AKR1B10 in healthy women and patients with a localized or …

BACKGROUND: The effect of GuizhiFuling Wan (GFW) on adenomyosis (AM) is definite. This study aimed to explore the mechanism and key therapeutic targets of GFW in treating AM through network pharmacology combined with molecular docking and e…

BACKGROUND: Atypical polypoid adenomyoma (APA) is a rare intrauterine polypoid lesion that occurs predominantly in premenopausal women. Although APA was previously considered a benign lesion and treated conservatively, an increasing number …