Huang O

No ORCID on file · 8 papers in corpus · active 2015-2024

Study types

  • article 3
  • other 1
  • preprint 1

Condition tags

  • adenomyosis 5
  • endometriosis 3
2024
A randomized, controlled clinical study of low-molecular-weight heparin improving pregnancy outcomes in PCOS women undergoing IVF: study protocol.
Trials ·doi:10.1186/s13063-023-07877-x

BackgroundPolycystic ovary syndrome (PCOS), an incidence of 10-15% in women of reproductive age, shows sex hormone disorders, luteal insufficiency, and the tendency of placental villus space thrombus. The incidence of early pregnancy loss i…

article 2022
miR-218-5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-00928-z

BACKGROUND: Our previous two-dimensional electrophoresis experiment showed that the expression of LASP1 in patients with endometriosis was significantly higher than that of control endometrium. However, the molecular mechanism by which LASP…

2021
Aberrant activation of the Hedgehog signaling pathway in granulosa cells from patients with polycystic ovary syndrome.
Bioengineered ·doi:10.1080/21655979.2021.2003943

The molecular mechanism that triggers polycystic ovary syndrome (PCOS) is mysterious. Abnormal development of ovarian granulosa cells (GCs) is one of the causes of PCOS. Herein, our study was carried out using RNA-seq to detect the differen…

2021
Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome.
Experimental and therapeutic medicine ·doi:10.3892/etm.2020.9463

Polycystic ovary syndrome (PCOS) affects 8-13% of reproductive-age females worldwide and mutations or aberrant expression of androgen receptor (AR) may cause the onset of this disease. In the present study, 258 samples from Han Chinese pati…

article 2021
Endometrial stromal cell proteomic analysis reveals LIM and SH3 protein 1 (LASP1) plays important roles in the progression of adenomyosis
Molecular human reproduction ·doi:10.1093/molehr/gaab008

Adenomyosis is one of the most common gynecological disorders that the molecular events underlying its pathogenesis remain not fully understood. Prior studies have shown that endometrial stromal cells (ESCs) played crucial roles in the path…

preprint 2021
miR-218-5p in Endometrial Microenvironment Prevents the Migration of Ectopic Endometrial Stromal Cells by Inhibiting LASP1
·doi:10.21203/rs.3.rs-600354/v1

Abstract Our previous two-dimensional electrophoresis experiments showed that the expression of LASP1 in patients with endometriosis was significantly higher than that of control endometrium. However, the molecular mechanism by which LASP1 …

article 2019
Inhibition of formin like 2 promotes the transition of ectopic endometrial stromal cells to epithelial cells in adenomyosis through a MET-like process
Gene ·doi:10.1016/j.gene.2019.06.003

EMT (Epithelial-Mesenchymal Transition) is one of the factors in the pathogenesis of adenomyosis. FMNL2 induced invasion of cancer cell through promoting EMT, but it is unclear the role of FMNL2 in the adenomyosis. By IHC staining, we found…

other 2015
Expression of DJ-1 and mTOR in eutopic and ectopic endometria of patients with endometriosis and adenomyosis
Gynecologic and obstetric investigation ·doi:10.1159/000365569

OBJECTIVE: Endometrial cells may aberrantly express molecules involved in invasion and migration, leading to endometriosis. The aim of this study was to investigate the expression of DJ-1 and phosphorylated mammalian target of rapamycin (p-…