Tonello R

No ORCID on file · 2 papers in corpus · active 2023-2025
2025
Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation.
Nature communications ·doi:10.1038/s41467-025-63782-8

Analgesia by non-steroidal anti-inflammatory drugs (NSAIDs) is ascribed to inhibition of prostaglandin (PG) biosynthesis and ensuing inflammation. However, NSAIDs have life-threatening side effects, and inhibition of inflammation delays pai…

2023
Neuropilin-1 is essential for vascular endothelial growth factor A-mediated increase of sensory neuron activity and development of pain-like behaviors.
Pain ·doi:10.1097/j.pain.0000000000002970

AbstractNeuropilin-1 (NRP-1) is a transmembrane glycoprotein that binds numerous ligands including vascular endothelial growth factor A (VEGFA). Binding of this ligand to NRP-1 and the co-receptor, the tyrosine kinase receptor VEGFR2, elici…