Akin JW

No ORCID on file · 5 papers in corpus · active 1992-2025

Study types

  • article 1
2025
The inhibition of prostaglandin production during ovulation by exposure to a phthalate mixture is circumvented by cAMP analogue supplementation in a human granulosa cell model.
Reproductive toxicology (Elmsford, N.Y.) ·doi:10.1016/j.reprotox.2025.108968

Exposure to individual phthalates disrupts ovarian function; however, the direct effects of phthalate mixture exposure on ovulation is unknown, especially in women. Human granulosa cells were used to test the hypothesis that exposure to a p…

2023
A single-cell gene expression atlas of human follicular aspirates: Identification of leukocyte subpopulations and their paracrine factors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology ·doi:10.1096/fj.202201746rr

Leukocytes are in situ regulators critical for ovarian function. However, little is known about leukocyte subpopulations and their interaction with follicular cells in ovulatory follicles, especially in humans. Single-cell RNA sequencing (s…

2023
Exposure to a phthalate mixture disrupts ovulatory progesterone receptor signaling in human granulosa cells in vitro†.
Biology of reproduction ·doi:10.1093/biolre/ioad091

Exposure to phthalates disrupts ovarian function. However, limited studies have investigated the effects of phthalate mixtures on ovulation, especially in women. Human granulosa cells were used to test the hypothesis that exposure to a phth…

2021
The FOS/AP-1 Regulates Metabolic Changes and Cholesterol Synthesis in Human Periovulatory Granulosa Cells.
Endocrinology ·doi:10.1210/endocr/bqab127

FOS, a subunit of the activator protein-1 (AP-1) transcription factor, has been implicated in various cellular changes. In the human ovary, the expression of FOS and its heterodimeric binding partners JUN, JUNB, and JUND increases in periov…

article 1992
The effects of spontaneous luteinizing hormone surges on superovulatory cycles
Fertility and Sterility ·doi:10.1016/s0015-0282(16)55321-7

ObjectiveTo determine the effect of a spontaneous luteinizing hormone (LH) surge on the cycle fecundity during superovulation induction.DesignSuperovulatory cycles of patients with various diagnoses are retrospectively compared.SettingRepro…