Idhaliz Flores

INTRODUCTION: Endometriosis is a chronic inflammatory gynecologic disease affecting 5-10% of women of reproductive age of all ethnicities. Symptoms of this painful condition impact the physical, mental health, and quality of life of patient…

We previously demonstrated the negative impact of stress in an animal model of endometriosis. Although its role is unclear, altered levels of vitamin D (VitD) have been found in patients with this condition. VitD signaling through the VitD …

Endometriosis is a painful gynecological disease with no cure and limited therapeutic options. It has been hypothesized that epigenetic drugs can be used as a nonhormonal treatment for endometriosis. This study was conducted to study the ef…

There is strong evidence from humans and animal models showing that abnormal functioning of the hypothalamic-pituitary-adrenal (HPA) axis and/or the inflammatory response system disrupts feedback regulation of both neuroendocrine and immune…

BACKGROUND: The goals of health disparities research are to identify facilitators and barriers to healthcare use to help eliminate health inequalities. There are few studies on disparities in healthcare access and use trends for patients wi…

Endometriosis is an inflammatory, painful gynecologic disease with no cure and limited treatment options. Epigenetics, including histone modifications, play a key role in the etiology of endometriosis, therefore it has been hypothesized tha…

Abstract Endometriosis is a disorder in which endometrial tissue is found outside the uterus causing pain, infertility and stress. Finding an effective and long-term treatment for endometriosis still remains one of the most significant chal…

Endometriosis is a disorder in which endometrial tissue is found outside the uterus causing pain, infertility and stress. Finding effective, non-hormonal and long-term treatments for endometriosis still remains one of the most significant c…

Endometriosis is an estrogen-dependent, inflammatory disease that affects 5-10% of women of reproductive age. It is defined as the growth of functioning endometrium outside the uterus that results in severe pelvic pain and often infertility…

Although the histone methyltransferase EZH2 and its product H3K27me3 are well studied in cancer, little is known about their role and potential as therapeutic targets in endometriosis. We have previously reported that endometriotic lesions …

Iron is proposed to contribute to the transition from endometriosis to specific subtypes of ovarian cancers (OVCAs). Regulation of intracellular iron occurs via a ferritinophagic process involving NCOA4 (Nuclear Receptor Coactivator 4), rep…

Most available therapies for endometriosis are hormone-based and generally broadly used without taking into consideration the ovarian hormone receptor expression status. This contrasts strikingly with the standard of care for other hormone-…

Purpose: Endometriosis is a hormone-dependent, inflammatory, painful condition affecting 1 in 10 women during their reproductive years. The symptoms of endometriosis-dysmenorrhea, dyspareunia, infertility-negatively impact the quality of li…

A noninvasive biomarker-based test could help shorten the diagnostic delay for endometriosis. The most investigated biomarker sources are peripheral blood and endometrium. Discovery of endometriosis biomarkers is often hypothesis-driven, i.…

Background Endometriosis, defined as the growth and development of endometrial like tissue, ( i.e., glands and stroma) outside the uterine cavity, is a gynecological condition that affects 10% of women in their reproductive age. Cumulative …

Treatments for endometriosis include pharmacological or surgical procedures that produce significant side effects. We aimed to determine how environmental enrichment (EE) could impact the progression of endometriosis using the autotransplan…

Treatments for endometriosis include pharmacological or surgical procedures that produce significant side effects. We aimed to determine how environmental enrichment (EE) could impact the progression of endometriosis using the autotransplan…

Treatments for endometriosis include pharmacological or surgical procedures that produce significant side effects. We aimed to determine how environmental enrichment (EE) could impact the progression of endometriosis using the autotransplan…

High levels of inflammatory factors including chemokines have been reported in peritoneal fluid and blood of women with endometriosis. CXCL12 mediates its action by interaction with its specific receptor, CXCR4, reported to be elevated in h…

PURPOSE: We have previously shown that stress prior to induction worsens clinical presentation and inflammatory parameters in a rat model of endometriosis. This study was designed to examine whether stress during the development of endometr…

Supp-Fig for Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression by Annelyn Torres-Reverón, Leslie L. Rivera, Idhaliz Flores, and Caroline B. Appleyard in Reproductive Sciences

Supp-Fig for Environmental Manipulations as an Effective Alternative Treatment to Reduce Endometriosis Progression by Annelyn Torres-Reverón, Leslie L. Rivera, Idhaliz Flores, and Caroline B. Appleyard in Reproductive Sciences

Abstract Background: Endometriosis is a benign gynecologic condition that is known to have transformation potential. Women with ovarian endometriosis have twice the risk for developing ovarian cancer of the endometrioid or clear cell types.…

In endometriosis, the increased survival potential of shed endometrial cells (which normally undergo anoikis) is suggested to promote lesion development. One mechanism that may alter anoikis is autophagy. Using an autophagic flux inhibitor …

Endometriosis is an estrogen-dependent gynecological disease that affects 1 out of 10 women of reproductive age causing severe pelvic pain and infertility. Factors including genetics, environment, inflammation, and recently epigenetics have…