Higuchi S

No ORCID on file · 3 papers in corpus · active 2016-2017

Study types

  • other 2

Condition tags

  • endometriosis 2
other 2017
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma
Applied immunohistochemistry & molecular morphology : AIMM ·doi:10.1097/PAI.0000000000000316

Sirtuin 1 (SIRT1), originally identified as a longevity gene, regulates DNA repair and metabolism by deacetylating target proteins such as p53. SIRT1 plays a key role in the pathophysiology of metabolic diseases and neurodegenerative disord…

2017
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells.
Translational oncology ·doi:10.1016/j.tranon.2017.05.005

BackgroundSIRT1 is a longevity gene that forestalls aging and age-related diseases including cancer, and has recently attracted widespread attention due to its overexpression in some cancers. We previously identified the overexpression of S…

other 2016
Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant
Free radical research ·doi:10.3109/10715762.2015.1134795

Ovarian clear cell carcinoma (CCC) arises from ovarian endometriosis. Intra-cystic fluid contains abundant amounts of free iron, which causes persistent oxidative stress, a factor that has been suggested to induce malignant transformation. …