Ryoichi Asaka

ORCID: 0000-0003-4450-5142 · 3 papers in corpus · active 2016-2023

Study types

  • other 2
  • article 1

Condition tags

  • endometriosis 3
article 2023
Establishment of a novel model of endometriosis-associated ovarian cancer by transplanting uterine tissue from Arid1a/Pten knockout mice
Scientific reports ·doi:10.1038/s41598-023-35292-4

Although endometriosis is primarily benign, it has been identified as a risk factor for endometriosis-associated ovarian cancer (EAOC). Genetic alterations in ARID1A, PTEN, and PIK3CA have been reported in EAOC; however, an appropriate EAOC…

other 2017
Overexpression of SIRT1 is Associated With Poor Outcomes in Patients With Ovarian Carcinoma
Applied immunohistochemistry & molecular morphology : AIMM ·doi:10.1097/PAI.0000000000000316

Sirtuin 1 (SIRT1), originally identified as a longevity gene, regulates DNA repair and metabolism by deacetylating target proteins such as p53. SIRT1 plays a key role in the pathophysiology of metabolic diseases and neurodegenerative disord…

other 2016
Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant
Free radical research ·doi:10.3109/10715762.2015.1134795

Ovarian clear cell carcinoma (CCC) arises from ovarian endometriosis. Intra-cystic fluid contains abundant amounts of free iron, which causes persistent oxidative stress, a factor that has been suggested to induce malignant transformation. …