Roth GS

No ORCID on file · 4 papers in corpus · active 2006-2017
2017
Caloric restriction improves health and survival of rhesus monkeys.
Nature communications ·doi:10.1038/ncomms14063

Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated t…

2012
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
Nature ·doi:10.1038/nature11432

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ag…

2007
Effects of calorie restriction on chromosomal stability in rhesus monkeys (Macaca mulatta).
Age (Dordrecht, Netherlands) ·doi:10.1007/s11357-006-9016-6

The basic tenet of several theories on aging is increasing genomic instability resulting from interactions with the environment. Chromosomal aberrations have been used as classic examples of increasing genomic instability since they demonst…

2006
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.
Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.0606661103

Caloric restriction (CR) has long been known to increase median and maximal lifespans and to decreases mortality and morbidity in short-lived animal models, likely by altering fundamental biological processes that regulate aging and longevi…