Wang Y

INTRODUCTION: Cisplatin resistance is a major challenge in ovarian cancer therapy, particularly for high-grade serous ovarian cancer (HGSOC). DNA topoisomerase IIα (TOP2A) relates to cancer drug resistance, yet its role and molecular mechan…

Ovarian cancer represents a malignancy characterized by high incidence and mortality rates, necessitating further elucidation of its underlying mechanisms. We conducted an analysis using bulk transcriptomic data of ovarian cancer and normal…

BACKGROUND: For patients with nodules detected in imaging that are indeterminate for malignancy, achieving accurate, early, and non-invasive diagnosis of Lung Squamous Cell Carcinoma (LUSC) remains a significant challenge. Therefore, we aim…

BACKGROUND: Embryo selection and preimplantation genetic testing (PGT) are used in clinical practice with the aim of improving pregnancy outcomes in patients. However, it remains uncertain whether different PGT techniques improve the live b…

BACKGROUND: LncRNA LINC02381 has emerged as a promising tumor biomarker; however, its involvement in the pathogenesis of pancreatic cancer remains unexplored at this time. The objective of this study is to elucidate the regulatory effect of…

Long non-coding RNAs (lncRNAs) affect the biological functions of granulosa cells (GCs) through multiple mechanisms, including epigenetic regulation, transcriptional regulation, post-translational modification, and cell signaling. Our previ…

PURPOSE: This study aimed to develop a joint model combining T2-weighted imaging (T2WI) suppressed fat radiomics, and clinical parameters to predict the energy efficiency factor (EEF) required for high-intensity focused ultrasound (HIFU) ab…

Atherosclerosis has an urgent need for new therapeutic targets. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, a protein kinase, WEE1 G2 checkpoint …

Infertility is an increasingly prevalent global health issue affecting millions of couples. It can arise from various factors, including hormonal imbalances, reproductive disorders, and anatomical abnormalities. While numerous treatment opt…

OBJECTIVES: To investigate the mechanism of medicinal cake-separated moxibustion in inhibiting the adhesion, invasion and angiogenesis of ectopic endometriotic tissues in endometriosis (EMs) rats through transforming growth factor-β1 (TGF-β…

BACKGROUND: Melatonin (MT) is involved in the regulation of various important biological processes related to reproduction. Many studies have investigated the effects of MT supplementation on outcomes following assisted reproductive technol…

Polycystic ovary syndrome (PCOS) is a prevalent gynecologic endocrine disorder characterized by menstrual irregularities, elevated androgen levels, and ovulatory dysfunction. Its etiology is multifactorial. Emerging evidence indicates that …

Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they ofte…

BACKGROUND: Comprehensive sonographic evaluation of pre- and postmenopausal women with abnormal uterine bleeding is essential for accurate diagnosis and the optimization of curative outcomes for endometrial malignancy. Microvascular flow im…

PURPOSE: Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including the reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers and women of reproductiv…

AIM: This study sought to design a multiparametric magnetic resonance imaging (MRI) radiomics machine learning model capable of predicting high-intensity focussed ultrasound (HIFU) ablation outcomes in adenomyosis, with the further implemen…

Rationale: Endometriosis, characterized by the presence of ectopic endometrial-like tissue, is a common chronic inflammatory disorder in gynecology. However, current treatments, including surgery and hormone therapy, often yield suboptimal …

The Body Roundness Index (BRI) is an innovative anthropometric measure reflecting body shape and obesity, increasingly recognized as a potential predictor of infertility, warranting further exploration. This research employed a cross-sectio…

BACKGROUND: Gastric-type endocervical adenocarcinoma (G-EAC) is a rare and aggressive subtype of cervical cancer which is not associated with human papillomavirus (HPV) infection but has poor prognosis because of its high invasiveness and r…

Mucinous cystic neoplasm of the liver (MCN-L) is a rare benign tumor accounting for less than 5% of all liver cysts, with MCN-L in the hilar region being exceptionally uncommon and often misdiagnosed due to its complex presentation. A 48-ye…

PURPOSE: This study aimed to investigate the impact of obstructive sleep apnea (OSA) on in vitro fertilization (IVF) and embryo transfer outcomes in infertile patients with polycystic ovary syndrome (PCOS). METHODS: We conducted a prospect…

Abdominal wall endometriosis (AWE), often post-cesarean, can cause massive abdominal wall defects following lesion resection. This report details a novel open technique for recurrent massive AWE in a 32-year-old female involving radical exc…

Palmitoylethanolamide (PEA) has attracted increasing attention from researchers as an endogenous lipid mediator. It exhibits a unique mechanism of action in alleviating pain, controlling inflammation, and providing neuroprotection. It prima…

STUDY QUESTION: Can algorithms using wrist temperature, available on compatible models of iPhone and Apple Watch, retrospectively estimate the day of ovulation and predict the next menses start day? SUMMARY ANSWER: Algorithms using wrist t…

The present study aimed to investigate the role of 6‑phosphofructo‑2‑kinase/fructose‑2,6‑biphosphatase 4 (PFKFB4) in endometrial cancer cells and to explore its potential molecular mechanisms. PFKFB4 expression in endometrial cancer tissues…