Yi-Rong Lee

No ORCID on file · 3 papers in corpus · active 2008-2022

Study types

  • article 2
  • dissertation 1

Condition tags

  • endometriosis 3
  • adenomyosis 2
article 2022
Osteopontin Splicing Isoforms Contribute to Endometriotic Proliferation, Migration, and Epithelial-Mesenchymal Transition in Endometrial Epithelial Cells
International journal of molecular sciences ·doi:10.3390/ijms232315328

Osteopontin (OPN) isoforms, including OPNb and OPNc, promote malignancy and may contribute to the pathogenesis of endometriosis, a benign disorder with multiple characteristics resembling malignant tumors. In our experiments, OPNb and OPNc …

article 2008
EL-004 Osteopontin in endometriosis
·doi:10.1016/s1472-6483(10)61570-2
dissertation 2008
The role of osteopontin in endometriosis

[[abstract]]子宮內膜異位是一種婦產科常見的疾病，而造成此疾病的發病過程及機轉並不清楚。近年來有研究指出在大鼠的子宮內膜異位的模式中，發現骨橋蛋白(osteopontin, OPN)在子宮組織內會大量表現。本論文主旨在探討OPN在子宮內膜異位的形成中所扮演的角色。首先，我們利用西方墨點法發現子宮內膜異位病患的子宮內膜組織、腹膜液、濾泡液和巧克力囊腫體液中OPN會大量表現。此外，我們並以子宮內膜HEC-1A 細胞為細胞模式，觀察OPN對子宮內膜細胞的移行、入侵和增生能…