José Javier Singla

No ORCID on file · 8 papers in corpus · active 1997-2022

Study types

  • article 8

Condition tags

  • endometriosis 7
  • infertility 2
article 2022
Endocrine disruptor hexachlorobenzene induces cell migration and invasion, and enhances aromatase expression levels in human endometrial stromal cells
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association ·doi:10.1016/j.fct.2022.112867

Endometriosis is the presence and growth of endometrial tissue outside of the uterus. Previous studies have suggested that endocrine disrupting chemicals such as organochlorine pesticides could be a risk factor for endometriosis. Hexachloro…

article 2020
Potential use of ellagic acid for endometriosis treatment: its effect on a human endometrial cell cycle, adhesion and migration
Food & function ·doi:10.1039/d0fo00267d

Endometriosis is a common and challenging condition of reproductive-aged women that is defined as the presence of endometrial-like tissue outside the uterine cavity. Despite its prevalence, there is still no effective therapeutics; so we ai…

article 2019
PI3K/AKT pathway is altered in the endometriosis patient’s endometrium and presents differences according to severity stage
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology ·doi:10.1080/09513590.2019.1680627

Based on the inflammatory nature and hormone-dependency of endometriosis, PI3K/AKT signaling appears to influence its progression. Could the endometriosis stages be linked to differential changes in PI3K/AKT pathway regulation? The objectiv…

article 2018
Active compounds present inRosmarinus officinalis leaves andScutellaria baicalensis root evaluated as new therapeutic agents for endometriosis
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2018.09.018

Research questionCan carnosic acid, (CA) rosmarinic acid (RA) and wogonin (WG) inhibit the growth of cultured human endometrial stromal cells and endometriotic-like lesions induced in a BALB/c model of endometriosis?DesignPrimary stromal ce…

article 2016
Enhanced cyclooxygenase-2 expression levels and metalloproteinase 2 and 9 activation by Hexachlorobenzene in human endometrial stromal cells
Biochemical pharmacology ·doi:10.1016/j.bcp.2016.03.024

Hexachlorobenzene (HCB) is an organochlorine pesticide that induces toxic reproductive effects in laboratory animals. It is a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR). Endometriosis is characterized by t…

article 2014
Targeting galectin‐1‐induced angiogenesis mitigates the severity of endometriosis
The Journal of Pathology ·doi:10.1002/path.4397

Endometriosis is characterized by the presence of endometrial tissue outside the uterus that causes severe pelvic pain and infertility in women of reproductive age. Although not completely understood, the pathophysiology of the disease invo…

article 2012
Natural therapies assessment for the treatment of endometriosis
Human Reproduction ·doi:10.1093/humrep/des369

STUDY QUESTION: Can resveratrol and epigallocatechin-3-gallate (EGCG) inhibit the growth and survival of endometriotic-like lesions in vivo in a BALB/c model of endometriosis, and in vitro in primary cultures of human endometrial epithelial…

article 1997
Effect of peritoneal fluid from patients with mild and severe endometriosis on endometrial stromal cell proliferation
Archives of gynecology and obstetrics ·doi:10.1007/bf02505318

The aim of this study was to evaluate and compare the mitogenic effect of peritoneal fluid (PF) from women with mild and severe endometriosis on the endometrial stromal cell proliferation. Increasing concentrations of PF from women with and…