Jake J Reske

No ORCID on file · 4 papers in corpus · active 2020-2022

Study types

  • other 3
  • article 1

Condition tags

  • endometriosis 3
  • infertility 1
  • adenomyosis 1
article 2022
AP-1 Subunit JUNB Promotes Invasive Phenotypes in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-022-00974-3

Endometriosis is a disease defined by the presence of abnormal endometrium at ectopic sites, causing pain and infertility in 10% of women. Mutations in the chromatin remodeling protein ARID1A (AT-rich interactive domain-containing protein 1…

other 2022
Endometrial Epithelial ARID1A Is Required for Uterine Immune Homeostasis during Early Pregnancy
International journal of molecular sciences ·doi:10.3390/ijms23116067

A growing body of work suggests epigenetic dysregulation contributes to endometriosis pathophysiology and female infertility. The chromatin remodeling complex subunit AT-rich interaction domain 1A (ARID1A) must be properly expressed to main…

other 2020
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
Cell reports ·doi:10.1016/j.celrep.2020.108366

Endometriosis affects 1 in 10 women and is characterized by the presence of abnormal endometrium at ectopic sites. ARID1A mutations are observed in deeply invasive forms of the disease, often correlating with malignancy. To identify epigene…

other 2020
SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity
Human molecular genetics ·doi:10.1093/hmg/ddaa227

Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related g…