Pinto S

No ORCID on file · 4 papers in corpus · active 2021-2026

Study types

  • other 2
other 2026
A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3
Communications chemistry ·doi:10.1038/s42004-026-01889-9

Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca2+-permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception. Moreover, gain-of-function variants in TRPM3 underlie a spectrum of ne…

other 2026
TRPM3 mediates spontaneous pain and mechanical allodynia in a mouse model of chronic orofacial neuropathy
Cell reports. Medicine ·doi:10.1016/j.xcrm.2026.102645

Trigeminal nerve injury can lead to chronic and difficult-to-treat orofacial neuropathic pain. Here, we uncover a key role for the cation channel TRPM3 in the chronic constriction injury of the infraorbital nerve (IoN-CCI) mouse model of tr…

2022
Ruptured ovarian ectopic pregnancy presenting with an acute abdomen.
BMJ case reports ·doi:10.1136/bcr-2022-252499

An ectopic pregnancy occurs in 2% of all pregnancies. A primary ovarian ectopic (OP) is a rare entity and occurs in <2% of all ectopic gestations. It may present in those individuals who take ovulatory drugs, use an intrauterine device or h…

2021
The TRPM3 ion channel mediates nociception but not itch evoked by endogenous pruritogenic mediators.
Biochemical pharmacology ·doi:10.1016/j.bcp.2020.114310

During the molecular transduction of itch, the stimulation of pruriceptors on sensory fibers leads to the activation or sensitization of ion channels, which results in a consequent depolarization of the neurons. These ion channels mostly be…