Laisk-Podar T

No ORCID on file · 9 papers in corpus · active 2014-2018

Study types

  • other 3
  • review 2
  • article 1

Condition tags

  • endometriosis 5
  • infertility 1
  • adenomyosis 1
review 2018
DNA methylation alterations—potential cause of endometriosis pathogenesis or a reflection of tissue heterogeneity?†
Biology of reproduction ·doi:10.1093/biolre/ioy067

Alterations in the DNA methylation pattern of endometriotic lesions and endometrium of endometriosis patients have been proposed as one potential factor accompanying the endometriosis development. Although many differentially methylated gen…

2018
Whole exome sequencing of benign pulmonary metastasizing leiomyoma reveals mutation in the BMP8B gene.
BMC medical genetics ·doi:10.1186/s12881-018-0537-5

BackgroundBenign metastasizing leiomyoma (BML) is an orphan neoplasm commonly characterized by pulmonary metastases consisting of smooth muscle cells. Patients with BML have usually a current or previous uterine leiomyoma, which is therefor…

review 2017
Challenges in endometriosis miRNA studies — From tissue heterogeneity to disease specific miRNAs
Biochimica et biophysica acta. Molecular basis of disease ·doi:10.1016/j.bbadis.2017.06.018

In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these tissues have been investigated and a large number of dysregula…

other 2017
DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase
Scientific reports ·doi:10.1038/s41598-017-03682-0

The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although not much is known about the endometrial methylome changes …

2017
Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers.
Scientific reports ·doi:10.1038/s41598-017-10098-3

Previous transcriptome studies of the human endometrium have revealed hundreds of simultaneously up- and down-regulated genes that are involved in endometrial receptivity. However, the overlap between the studies is relatively small, and we…

other 2017
Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues
Epigenetics ·doi:10.1080/15592294.2017.1367475

Genome-wide association studies in the fields of reproductive medicine and endocrinology are yielding robust genetic variants associated with disease. Integrated genomic, transcriptomic, and epigenomic molecular profiling studies are common…

2016
Single-cell transcriptome analysis of endometrial tissue.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dew008

Study questionHow can we study the full transcriptome of endometrial stromal and epithelial cells at the single-cell level?Summary answerBy compiling and developing novel analytical tools for biopsy, tissue cryopreservation and disaggregati…

other 2015
Pregnancy rate in endometriosis patients according to the severity of the disease after using a combined approach of laparoscopy, GnRH agonist treatment and in vitro fertilization
Gynecologic and obstetric investigation ·doi:10.1159/000365329

AIM: To evaluate the effects of combined treatment approaches on endometriosis-associated infertility in different stages of endometriosis using laparoscopy, gonadotropin-releasing hormone (GnRH) agonist (GnRHa) therapy and in vitro fertili…

article 2014
High-Throughput Sequencing Approach Uncovers the miRNome of Peritoneal Endometriotic Lesions and Adjacent Healthy Tissues
PloS one ·doi:10.1371/journal.pone.0112630

Accumulating data have shown the involvement of microRNAs (miRNAs) in endometriosis pathogenesis. In this study, we used a novel approach to determine the endometriotic lesion-specific miRNAs by high-throughput small RNA sequencing of paire…