Zedeler A

ORCID: 0000-0003-1394-9138 · 12 papers in corpus
2026
Does intracytoplasmic sperm injection outperform conventional in vitro fertilization in couples without severe male factor infertility? A systematic review and meta-analysis of randomized controlled trials.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/deag066

Study questionDoes ICSI improve the live birth rate in couples without severe male factor infertility compared to conventional IVF (cIVF)?Summary answerHigh-quality evidence showed no benefit of ICSI over cIVF in improving live birth or cum…

2025
IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial.
Nature medicine ·doi:10.1038/s41591-025-03621-x

Intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (c-IVF) are widely used fertilization techniques in assisted reproduction, but their relative effectiveness in patients without severe male factor infertility r…

2025
Maternal-Fetal Outcomes and Antibody Transfer, Depending on the Trimester of SARS-CoV-2 Infection in Non-Vaccinated Women-A Danish Nationwide Prospective Cohort Study.
International journal of molecular sciences ·doi:10.3390/ijms26062533

Passive maternal-fetal transfer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies has been demonstrated, whilst the degree of transfer depending on the trimester of infection is lacking. Due to neonates' immature im…

2024
Immune changes in pregnancy: associations with pre-existing conditions and obstetrical complications at the 20th gestational week-a prospective cohort study.
BMC medicine ·doi:10.1186/s12916-024-03797-y

BackgroundPregnancy is a complex biological process and serious complications can arise when the delicate balance between the maternal and semi-allogeneic fetal immune systems is disrupted or challenged. Gestational diabetes mellitus (GDM),…

2023
Immune Changes in Pregnancy: Associations with Pre-existing Conditions and Obstetrical Complications at the 20th Gestational Week - A Prospective Cohort Study
·doi:10.1101/2023.08.10.23293934

Background Pregnancy is a complex biological process and serious complications can arise when the delicate balance between the maternal immune system and the semi-allogeneic fetal immune system is disrupted or challenged. Gestational diabet…

2022
Binucleated embryos at the two-cell stage show higher blastocyst formation rates and higher pregnancy and live birth rates compared to non-multinucleated embryos.
Human reproduction open ·doi:10.1093/hropen/hoac049

Study questionHow does nucleus status at the two-cell stage predict blastocysts formation and clinical outcome after single blastocyst transfer?Summary answerBinucleated embryos at the two-cell stage (2BI) show higher rates of good quality …

2022
Is paternal age associated with transfer day, developmental stage, morphology, and initial hCG-rise of the competent blastocyst leading to live birth? A multicenter cohort study.
PloS one ·doi:10.1371/journal.pone.0270664

In this study we investigated whether age of men undergoing assisted reproductive technology (ART) treatment was associated with day of transfer, stage, morphology, and initial hCG-rise of the competent blastocyst leading to a live birth? T…

2021
In vitro fertilisation (IVF) versus intracytoplasmic sperm injection (ICSI) in patients without severe male factor infertility: study protocol for the randomised, controlled, multicentre trial INVICSI.
BMJ open ·doi:10.1136/bmjopen-2021-051058

IntroductionOver the last decades, the use of intracytoplasmic sperm injection (ICSI) has increased, even among patients without male factor infertility. The increase has happened even though there is no evidence to support that ICSI result…

2021
RUBIC (ReproUnion Biobank and Infertility Cohort): A binational clinical foundation to study risk factors, life course, and treatment of infertility and infertility-related morbidity.
Andrology ·doi:10.1111/andr.13063

BackgroundInfertility affects 15%-25% of all couples during their reproductive life span. It is a significant societal and public health problem with potential psychological, social, and economic consequences. Furthermore, infertility has b…

2020
Freeze-all versus fresh blastocyst transfer strategy during in vitro fertilisation in women with regular menstrual cycles: multicentre randomised controlled trial.
BMJ (Clinical research ed.) ·doi:10.1136/bmj.m2519

ObjectiveTo compare the ongoing pregnancy rate between a freeze-all strategy and a fresh transfer strategy in assisted reproductive technology treatment.DesignMulticentre, randomised controlled superiority trial.SettingOutpatient fertility …

2019
Prediction of the lower serum anti-Müllerian hormone threshold for ovarian stimulation prior to in-vitro fertilization using the Elecsys® AMH assay: a prospective observational study.
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-019-0452-4

BackgroundIn assisted reproductive technology, prediction of treatment failure remains a great challenge. The development of more sensitive assays for measuring anti-Müllerian hormone (AMH) has allowed for the possibility to investigate if …

2017
Comparison of a 'freeze-all' strategy including GnRH agonist trigger versus a 'fresh transfer' strategy including hCG trigger in assisted reproductive technology (ART): a study protocol for a randomised controlled trial.
BMJ open ·doi:10.1136/bmjopen-2017-016106

IntroductionPregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained after fresh embryo transfer. This is partly due to improved laboratory techniques, but may…