Julian C. Knight

ORCID: 0000-0002-0377-5536 · 4 papers in corpus
article 2025
The phenotypic and genetic association between endometriosis and immunological diseases
Human Reproduction ·doi:10.1093/humrep/deaf062

STUDY QUESTION: Is there an increased risk of immunological diseases among endometriosis patients, and does a shared genetic basis contribute to this risk? SUMMARY ANSWER: Endometriosis patients show a significantly increased risk of autoi…

preprint 2024
The Association between Endometriosis and Immunological diseases
·doi:10.1101/2024.07.08.24310092

Abstract The evidence for a greater prevalence of immunological-diseases among endometriosis patients has varied in robustness and been subject to selection bias. We investigated the phenotypic and genetic association between endometriosis …

review 2019
The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis
Human Reproduction Update ·doi:10.1093/humupd/dmz014

BACKGROUND: Endometriosis is a chronic gynaecological disorder that affects 2-10% of women of reproductive age. The aetiology of endometriosis is largely under-explored, yet abnormalities in the immune system have been suggested to explain …

2016
The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.
Annals of the rheumatic diseases ·doi:10.1136/annrheumdis-2015-207490

ObjectivesTo identify the functional basis for the genetic association of single nucleotide polymorphisms (SNP), upstream of the RUNX3 promoter, with ankylosing spondylitis (AS).MethodsWe performed conditional analysis of genetic associatio…