Sornakala Ganeshkumar

lab-animal 2025

Loss of PRICKLE1 leads to abnormal endometrial epithelial architecture, decreased embryo implantation, and reduced fertility in mice

PNAS nexus ·doi:10.1093/pnasnexus/pgaf024

Successful embryo implantation requires coordinated changes in the uterine luminal epithelium, including structural adaptations, apical-basal polarity shifts, intrauterine fluid resorption, and cellular communication. Planar cell polarity p…

lab-animal 2024

Loss of PRICKLE1 leads to subfertility, aberrant extracellular matrix and abnormal myometrial architecture in mice

Reproduction (Cambridge, England) ·doi:10.1530/rep-24-0344

IN BRIEF: PRICKLE1, a WNT/planar cell polarity (PCP) protein that is downregulated in uterine leiomyoma, plays an important role in myometrial tissue architecture and extracellular matrix (ECM) deposition. This paper shows that myometrial-s…

lab-animal 2022

Loss of REST in breast cancer promotes tumor progression through estrogen sensitization, MMP24 and CEMIP overexpression

BMC cancer ·doi:10.1186/s12885-022-09280-2

BACKGROUND: Breast cancer is the most common malignancy in women, and is both pathologically and genetically heterogeneous, making early detection and treatment difficult. A subset of breast cancers express normal levels of REST (repressor …

lab-animal 2022

Loss of the repressor REST affects progesterone receptor function and promotes uterine leiomyoma pathogenesis

Proceedings of the National Academy of Sciences of the United States of America ·doi:10.1073/pnas.2205524119

Uterine leiomyomas (UL) are benign tumors that arise in the myometrial layer of the uterus. The standard treatment option for UL is hysterectomy, although hormonal therapies, such as selective progesterone receptor modulators, are often use…