Huang Y

PURPOSE: The growing antimicrobial resistance in Neisseria gonorrhoeae (N. gonorrhoeae) complicates the elimination of gonococcal infections and increases the risk of female infertility. In this study, we investigated the antimicrobial susc…

Diminished ovarian reserve (DOR) is associated with poor reproductive outcomes; however, the underlying molecular mechanisms-particularly those involving the regulation of granulosa cell (GC) function by exosomal microRNAs (miRNAs) derived …

Endometriosis is a common gynecological disease with high recurrence rates after surgery and the lesions keep unlimited proliferative capacity. The effect of garcinol on cell proliferation has not been investigated in endometriosis. Herein,…

OBJECTIVE: To evaluate the association of high-intensity focused ultrasound (HIFU) combined with syndrome differentiation-based individualized traditional Chinese medicine (TCM) herbal therapy with 12-month clinical outcomes compared with H…

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder characterized by ectopic endometrial tissue growth, leading to chronic inflammation and pelvic pain. Despite its high prevalence, the molecular mechanisms underlying EMs rem…

Cytoreductive surgery is the treatment protocol for colorectal cancer. Nonetheless, a major medical challenge remains to fully eliminate malignant tumor cells, along with a number of complications such as peritoneal adhesion and tumor perit…

ObjectiveThis study aims to investigate the role and regulatory mechanisms of PTP1B in acute pancreatitis.MethodsAn in vitro AP cell model was established using Caerulin (CAE). Cells were subsequently treated with MSI-1436 (PTP1B inhibitor)…

OBJECTIVE: To evaluate the association between medication for opioid use disorder (MOUD) and surgical complications and health care utilization among patients with opioid use disorder (OUD) undergoing hysterectomy. METHODS: Using MarketSca…

Uterine adenomyosis is a widespread condition that impairs female fertility, with elevated serum levels of cancer antigen 125 (CA125) and prolactin (PRL) often observed in affected women. Mifepristone has been investigated as a potential th…

Recent studies have highlighted the crucial role of mechanical properties in the ovarian microenvironment for ovarian function. However, the mechanisms that cause ovarian matrix stiffening during aging remain incompletely understood. Here w…

BACKGROUND: Optimal endometrial thickness and receptivity, precisely regulated by steroid hormones, are critical determinants for successful embryo implantation. Thin endometrium is a major cause of female infertility, yet its pathogenesis …

PURPOSE: This study aimed to develop a predictive model for diminished ovarian reserve (DOR) in reproductive-aged women with Hashimoto's thyroiditis (HT) by integrating transvaginal three-dimensional ultrasound and clinical multimodal data,…

PURPOSE: Embryo cryopreservation plays an essential role in assisted reproductive technology (ART). Vitrification has gradually replaced slow-freezing of embryos. In this study we investigated the effects of embryo vitrification on neonatal…

Endometriosis (EM) is a prevalent gynecological disorder linked to pelvic pain, menstrual disturbances, and infertility. Despite its clinical burden, the molecular mechanisms underlying EM remain elusive, necessitating the discovery of nove…

RESEARCH QUESTION: Is there a relationship between the location of adenomyosis lesions and obstetric and neonatal outcomes? DESIGN: A total of 466 women diagnosed with adenomyosis via transvaginal ultrasound between January 2019 and Decemb…

BACKGROUND: Endometriosis is a chronic inflammatory gynecologic disorder associated with pelvic pain and impaired health-related quality of life (HRQoL). Omega-3 polyunsaturated fatty acids (PUFAs) have anti-inflammatory potential and may c…

BACKGROUND: In-vitro-fertilization (IVF) failure rates remain above 65% with unknown causes. Uterine receptivity, largely determined by uterine peristalsis, is believed to play a key role in the IVF success. Accurate assessment of uterine p…

Perfluorooctanoic acid (PFOA) has been implicated in female reproductive toxicity, while its long-term effects of prenatal exposure remain unclear. Herein, we conducted a comprehensive NHANES analysis to estimate the Hazard Ratio (HR) of ea…

PURPOSE: To investigate the hypothesis that an imbalance between the epithelial adhesion molecule E-cadherin and matrix metalloproteinases (MMPs) underlies the vaginal atrophy associated with menopause. METHODS: This cross-sectional study …

sFRP2, a member of the secreted frizzled-related protein family, is an extracellular protein characterized by a cysteine-rich domain and a netrin-like (NTR) domain. By modulating ligand availability, receptor selection, and microenvironment…

BACKGROUND: Environmental exposure to trace and heavy metals may influence female fertility, yet their impact on assisted reproductive outcomes remains poorly defined. Maternal diet can potentially modulate metal-related toxicity by influen…

BACKGROUND: The underlying corticostriatal mechanisms of sex and hormonal effects in addiction are unknown, limiting the development of personalized treatments. METHODS: Thirty-two women (age = 38.85 ± 9.84 years) with heroin use disorder …

Female reproductive disorders influence women's physical and mental well-being, and the sustainability of the family. However, it is unclear whether lifestyle factors, including sedentary behaviors and physical activity, could impact them. …

OBJECTIVES: This study aimed to comprehensively examine coagulation parameters in patients with endometriosis versus those without to determine hematologic alterations associated with endometriosis. METHODS: Embase, PubMed, CINAHL, Web of S…

OBJECTIVE: This study compares short-term effects of thermal ablation techniques, alone or with medications, on dysmenorrhea, menstrual volume, uterine size, and lesion size post-medication cessation. METHODS: Searches were conducted on Pu…