Liang Sun

ORCID: 0000-0002-0080-0855 · 5 papers in corpus
other 2024
Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice
Science translational medicine ·doi:10.1126/scitranslmed.adk8230

Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up to 15% of women and transgender men. Current treatments are ineffective for a substantial proportion of patients, underscoring the need for addition…

preprint 2023
Nociceptor to macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth
·doi:10.1101/2023.08.28.555101

Abstract Endometriosis is a debilitating and painful gynecological inflammatory disease affecting approximately 15% of women. Current treatments are ineffective for a significant fraction of patients, underscoring the need for new medical t…

article 2015
rhTNFR: Fc Suppresses the Development of Endometriosis in a Mouse Model by Downregulating Cell Proliferation and Invasiveness
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115620495

Tumor necrosis factor α (TNF-α), a proinflammatory cytokine, may play an important role in the pathogenesis of endometriosis; therefore, TNF-α inhibitors potentially have an effect on endometriosis. To investigate the effect of anti-TNF-α t…

article 2010
The remedial effect of soluble interleukin-1 receptor type II on endometriosis in the nude mouse model
Journal of biomedical research ·doi:10.1016/s1674-8301(10)60007-3

ObjectiveRecent studies have shown that the local expression of soluble interleukin (IL) -1 receptor type II (sIL-1 RII) in endometrial tissue of women with endometriosis is decreased, and the depression of IL-1 RII was more significant in …

article 2009
Cytokine array analysis of peritoneal fluid between women with endometriosis of different stages and those without endometriosis
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals ·doi:10.3109/13547500903183970

Cytokines are key mediators of intercellular communication and are likely to promote the development and progression of endometriosis. Previous studies provided evidence that endometriosis develops as a result of the pathogenetic factors in…