Claussnitzer M

No ORCID on file · 3 papers in corpus · active 2020-2025
2025
Scalable Deep Learning of Histology Images Reveals Genetic and Phenotypic Determinants of Adipocyte Hypertrophy
·doi:10.1101/2025.02.11.25322053

Background White adipose tissue dysfunction has emerged as a critical factor in cardiometabolic disease development, yet the cellular microstructure and genetic architecture of adipocyte morphology remain poorly explored. Methods We intro…

2022
A single-cell atlas of human and mouse white adipose tissue.
Nature ·doi:10.1038/s41586-022-04518-2

White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipi…

2020
Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits.
PLoS computational biology ·doi:10.1371/journal.pcbi.1008044

Genetic studies have recently highlighted the importance of fat distribution, as well as overall adiposity, in the pathogenesis of obesity-associated diseases. Using a large study (n = 1,288) from 4 independent cohorts, we aimed to investig…