Kazunori Imada

No ORCID on file · 7 papers in corpus · active 2007-2025

Study types

  • article 6
  • review 1

Condition tags

  • endometriosis 3
article 2025
Novel screening approach for stem cell selective inhibitors and their possible translational therapeutic potential for endometriosis
Reproductive biology ·doi:10.1016/j.repbio.2024.100992

Endometriosis is an estrogen-dependent benign disease characterized by growth of the endometrial tissue outside the uterine wall. Several reports suggest the possibility of the pathogenesis and recurrence of endometriosis being related to f…

article 2014
Dienogest, a synthetic progestin, down-regulates expression of CYP19A1 and inflammatory and neuroangiogenesis factors through progesterone receptor isoforms A and B in endometriotic cells
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2014.12.008
article 2013
Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-α or interleukin-1β
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.10.038
article 2011
Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells
·doi:10.1016/j.fertnstert.2011.09.040
review 2009
Pharmacological and clinical profile of dienogest (DINAGEST Tab. 1 mg)
Nihon yakurigaku zasshi. Folia pharmacologica Japonica ·doi:10.1254/fpj.133.32

ジエノゲスト（販売名：ディナゲスト錠1 mg）は，プロゲステロン受容体に対して選択的なアゴニスト活性を示す第4世代のプロゲスチンである．ジエノゲストは，ラットおよびウサギに経口投与することによりプロゲステロン作用を示し，一方，アンドロゲン作用，グルココルチコイド作用およびミネラルコルチコイド作用は示さなかった．ジエノゲストは，カニクイザルに反復経口投与することにより月経周期の停止，月経周期に伴う血中エストラジオール濃度の上昇および黄体形成ホルモン濃度の上昇を抑制し，卵巣機能抑…

article 2008
Dienogest, a selective progestin, reduces plasma estradiol level through induction of apoptosis of granulosa cells in the ovarian dominant follicle without follicle-stimulating hormone suppression in monkeys
·doi:10.1007/bf03345616
article 2007
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
·doi:10.1016/j.steroids.2007.10.003