Ren-Chin Wu

No ORCID on file · 7 papers in corpus · active 2014-2023

Study types

  • other 4
  • article 3

Condition tags

  • endometriosis 6
  • mesh:D004715 3
  • adenomyosis 2
  • infertility 1
  • die_deep_infiltrating 1
article 2023
Targeted next-generation sequencing for the detection of cancer-associated somatic mutations in adenomyosis
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology ·doi:10.1080/01443615.2022.2161352

Adenomyosis is a condition characterised by the invasion of endometrial tissues into the uterine myometrium, the molecular pathogenesis of which remains incompletely elucidated. Lesion profiling with next-generation sequencing (NGS) can lea…

other 2021
Molecular evidence for a clonal relationship between synchronous uterine endometrioid carcinoma and ovarian clear cell carcinoma: a new example of "precursor escape"?
Journal of molecular medicine (Berlin, Germany) ·doi:10.1007/s00109-021-02064-4

Synchronous endometrial and ovarian carcinomas (SEOCs) that share the same endometrioid histology are generally considered as the result of metastatic spread from one organ to another. However, SEOCs with different histologies are regarded …

other 2021
Serum levels of alpha1-antitrypsin isoforms in patients with ovarian clear cell carcinoma: An exploratory study
Journal of the Chinese Medical Association : JCMA ·doi:10.1097/JCMA.0000000000000604

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is frequently associated with endometriosis. Since serum levels of cancer antigen 125 (CA125) have limited diagnostic and prognostic value in this malignancy, there is an unmet need for reliab…

article 2018
Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis
PloS one ·doi:10.1371/journal.pone.0190573

Stress-induced phosphoprotein-1 (STIP1), an adaptor protein that coordinates the functions of HSP70 and HSP90 in protein folding, has been implicated in the development of human gynecologic malignancies. This case-control study investigates…

article 2017
Cancer-Associated Mutations in Endometriosis without Cancer
The New England journal of medicine ·doi:10.1056/nejmoa1614814

BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benig…

other 2017
CCNE1 copy-number gain and overexpression identify ovarian clear cell carcinoma with a poor prognosis
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc ·doi:10.1038/modpathol.2016.160

Ovarian clear cell carcinoma is a unique type of ovarian cancer, often derived from endometriosis, and advanced-stage disease has a dismal prognosis primarily due to the resistance to conventional chemotherapy. Previous studies have shown f…

other 2014
Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy
The Journal of Pathology ·doi:10.1002/path.4315

Up-regulated expression of telomerase reverse transcriptase (TERT) and subsequent maintenance of telomere length are essential in tumour development. Recent studies have implicated somatic gain-of-function mutations at the TERT promoter as …