Li Y

Uterine fibroids are common among women of reproductive age and often recur after treatment. Accurate recurrence prediction is essential for guiding clinical decisions, yet existing models remain inadequate. This study aimed to develop a no…

Diabetic kidney disease (DKD) is recognized as one of the leading causes of chronic kidney disease (CKD) and end-stage kidney disease (ESKD) worldwide, representing a rapidly growing global public health concern. Despite significant advance…

BackgroundThe Coronavirus disease 2019 (COVID-19) pandemic has significantly impacted global health and shares several clinical features with ulcerative colitis (UC). However, the existence of a common pathological mechanism between COVID-1…

BackgroundThis study aims to identify the optimal dominant follicle size on the trigger day in patients with ovulatory dysfunction and unexplained infertility undergoing intrauterine insemination with letrozole (LE-IUI) cycles.MethodsA retr…

Abstract Uterine peristalsis involves spontaneous, mild contractions of the sub-endometrial layer in the nonpregnant uterus, playing a crucial role in menstruation and fertility. Disruptions in peristaltic patterns have been linked to cond…

Study questionWhat are the impacts of different male infertility factors on embryological, cumulative pregnancy and neonatal outcomes of IVF/ICSI cycles?Summary answerSome severe male infertility factors, i.e. severe oligoasthenozoospermia …

ObjectivesWhether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes.DesignA retrospective cohort study.SettingWenzhou, Zhengjiang Province, China.Popula…

BackgroundThe weekend effect is a controversial epidemiological phenomenon that has rarely been reported in the assisted reproductive technology (ART) setting, particularly among first-cycle fresh embryo transfer (ET) populations undergoing…

Goserelin is widely used for prostate cancer, but drug-induced liver injury (DILI) has been rarely reported. We present a patient who developed ALT/AST elevations after each subcutaneous injection, followed by improvement after withdrawal a…

In clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (ClinS…

BackgroundsThe study was designed to analyze early pregnancy loss rates in first-time fresh embryo transfer cycles in low prognosis patients according to the POSEIDON criteria.MethodsThis was a retrospective cohort study, including patients…

ObjectiveThis study aimed to analyze the effect of progesterone (P) levels on the human chorionic gonadotropin (hCG) trigger day and the progesterone on hCG day-to-basal progesterone (PhCG/Pbasal) ratio on pregnancy outcomes in patients wit…

ObjectiveTo evaluate the efficacy and safety of the Peiyu Granules (PYG) compared with placebo on early miscarriage rates among women undergoing embryo transfer.MethodsA double-blind, parallel-group randomized clinical trial between Februar…

ObjectiveTo investigate the effects of cold environment exposure on female reproductive capacity and explore its potential regulatory mechanisms.MethodsFemale mice were subjected to cold water immersion to simulate cold environment exposure…

Study questionDoes the type of embryo culture medium affect the birthweight of newborns conceived by ART?Summary answerAfter fresh embryo transfers, singleton newborns in the G5 and HTF groups exhibited higher birthweight z-scores and incre…

ObjectiveA growing number of research papers have looked at the influence of exercise on pain severity in people with primary dysmenorrhea, but the findings have been inconsistent. The purpose of this research was to thoroughly evaluate the…

ObjectiveThis study aimed to investigate whether endometrial thickness (EmT) change prognosticates the ongoing pregnancy rate (OPR) in hormonally prepared frozen-thawed embryo transfers (FETs) in women with treated intrauterine adhesion (IU…

As a complex chronic gynecological disorder characterized by multifaceted etiology involving genetics, environment, immunity and inflammation, endometriosis (EM) has long been a significant concern for women of reproductive age worldwide. T…

BACKGROUND: Endometriosis and body mass index (BMI) are known to influence reproductive outcomes, but their combined impact on in vitro fertilization (IVF) success remains uncertain. OBJECTIVE: To evaluate the relationship between BMI and …

BackgroundUterine artery embolization (UAE) is a vital treatment modality for various gynecological conditions. However, complications may arise from the accidental migration of embolic agents into non-target tissues through the uterine art…

Ovarian clear cell carcinoma (OCCC) represents a rare and aggressive subtype of epithelial ovarian cancer with distinctive clinical and molecular characteristics. However, the identification, origin, and molecular features of the malignant …

BackgroundThe risk of ectopic pregnancy (EP) is known to increase with assisted reproductive technology (ART), but the specific risk factors are unclear.MethodsWe screened 6872 cycles for clinical data that met our study's inclusion criteri…

PurposeThis study aims to establish a single-time point RNA-sequencing-based endometrial receptivity test (rsERT) to provide hourly precision of endometrial WOI for patients with recurrent implantation failure (RIF).MethodsA two-phase study…

Since the birth of the first infant conceived through assisted reproductive technology (ART) in 1978, over 10 million individuals worldwide have been born using these methods. ART has offered hope to many facing infertility. However, concer…

Ferredoxins (FDXs) are evolutionarily conserved iron-sulfur (Fe-S) proteins that serve as master regulators of mitochondrial redox homeostasis, governing critical processes including electron transfer, energy metabolism, Fe-S cluster biogen…