Cai KQ

No ORCID on file · 3 papers in corpus · active 2006-2016
2016
Follicle Depletion Provides a Permissive Environment for Ovarian Carcinogenesis.
Molecular and cellular biology ·doi:10.1128/mcb.00202-16

We modeled the etiology of postmenopausal biology on ovarian cancer risk using germ cell-deficient white-spotting variant (Wv) mice, incorporating oncogenic mutations. Ovarian cancer incidence is highest in peri- and postmenopausal women, a…

2007
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
The American Journal of Pathology ·doi:10.2353/ajpath.2007.060769

Menopausal ovaries undergo morphological changes, known as ovarian aging, which are implicated in the high incidence of ovarian cancer occurring during the perimenopausal and immediate postmenopausal periods. The germ cell-deficient Wv mice…

2006
Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background.
The American Journal of Pathology ·doi:10.2353/ajpath.2006.060036

Disabled-2 (Dab2) is a phosphoprotein involved in cellular signal transduction and endocytic trafficking. The expression of Dab2 is frequently lost or suppressed in several epithelial tumors, and studies of its cellular function and growth …