Klein-Szanto A

No ORCID on file · 3 papers in corpus · active 2006-2010
2010
Development of a syngeneic mouse model of epithelial ovarian cancer.
Journal of ovarian research ·doi:10.1186/1757-2215-3-24

BackgroundMost cases of ovarian cancer are epithelial in origin and diagnosed at advanced stage when the cancer is widely disseminated in the peritoneal cavity. The objective of this study was to establish an immunocompetent syngeneic mouse…

2007
A reduction of cyclooxygenase 2 gene dosage counters the ovarian morphological aging and tumor phenotype in Wv mice.
The American Journal of Pathology ·doi:10.2353/ajpath.2007.060769

Menopausal ovaries undergo morphological changes, known as ovarian aging, which are implicated in the high incidence of ovarian cancer occurring during the perimenopausal and immediate postmenopausal periods. The germ cell-deficient Wv mice…

2006
Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background.
The American Journal of Pathology ·doi:10.2353/ajpath.2006.060036

Disabled-2 (Dab2) is a phosphoprotein involved in cellular signal transduction and endocytic trafficking. The expression of Dab2 is frequently lost or suppressed in several epithelial tumors, and studies of its cellular function and growth …