Shimada H

No ORCID on file · 9 papers in corpus · active 2016-2025

Study types

  • other 4
  • case-report 1
  • review 1

Condition tags

  • endometriosis 5
  • adenomyosis 1
case-report 2025
Journal of medical case reports ·doi:10.1186/s13256-025-05448-z

BACKGROUND: High-grade endometrial stromal sarcoma is a rare and aggressive subtype of uterine sarcoma, characterized by a poor prognosis. While typical initial manifestations include gynecological symptoms such as abnormal vaginal bleeding…

2025
Tissue barriers ·doi:10.1080/21688370.2024.2361976

The bicellular tight junction molecule cingulin (CGN) binds to microtubules in centrosomes. Furthermore, CGN contributes to the tricellular tight junction (tTJ) proteins lipolysis-stimulated lipoprotein receptor (LSR) and tricellulin (TRIC)…

other 2024
Tissue barriers ·doi:10.1080/21688370.2024.2304443

It is known that there are abnormalities of tight junction functions, cell migration and mitochondrial metabolism in human endometriosis and endometrial carcinoma. In this study, we investigated the effects of growth factors and their inhib…

2023
Tissue barriers ·doi:10.1080/21688370.2022.2106113

Lipolysis-stimulated lipoprotein receptor (LSR), a lipid metabolism-related factor localized in tricellular tight junctions (tTJs), plays an important role in maintaining the epithelial barrier. LSR is highly expressed in well-differentiate…

review 2021
Cancers ·doi:10.3390/cancers13246341

Tight junction proteins play roles beyond permeability barriers functions and control cell proliferation and differentiation. The relation between tight junctions and the signal transduction pathways affects cell growth, invasion and migrat…

other 2020
Histochemistry and cell biology ·doi:10.1007/s00418-020-01876-8

Apoptosis-stimulating p53 protein 2 (ASPP2) is an apoptosis inducer that acts via binding with p53 and epithelial polarity molecule PAR3. Lipolysis-stimulated lipoprotein receptor (LSR) is an important molecule at tricellular contacts, and …

other 2020
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-020-00230-6

Claudin-2 (CLDN-2) is a leaky-type tight junction protein, and its overexpression increases tumorigenesis of some types of cancer cells. In the present study, to examine the possibility of targeting CLDN-2 in the therapy for endometrioid en…

2017
Scientific reports ·doi:10.1038/srep37049

Lipolysis-stimulated lipoprotein receptor (LSR) is a unique molecule of tricellular contacts of normal and cancer cells. We investigated how the loss of LSR induced cell migration, invasion and proliferation in endometrial cancer cell line …

other 2016
Oncotarget ·doi:10.18632/oncotarget.8408

Lipolysis-stimulated lipoprotein receptor (LSR) has been identified as a novel molecular constituent of tricellular contacts that have a barrier function for the cellular sheet. LSR recruits tricellulin (TRIC), which is the first molecular …