Paola Viganò

Moreira and Oliveira highlight the shortcomings of the current management of endometriosis symptoms based on exclusively lesion-centred models, and promote patient categorisation according to an individual's predominant neurobiological mech…

BACKGROUND: In the field of in vitro fertilization (IVF), the search for reliable success predictors is ongoing, with novel biomarkers gaining increasing attention. Epigenetic clocks, mathematical models based on DNA methylation (DNAm) patt…

BACKGROUND: Pregnancy involves a fine-tuned hormonal interplay between the fetus, placenta, and mother, which shapes long-term developmental outcomes. Endometriosis has been hypothesized to originate in utero due to altered fetal exposure t…

STUDY QUESTION: What is the evidence available concerning gut and reproductive tract microbiomes in patients with endometriosis and what are the methodological approaches employed in microbiome studies on endometriosis? SUMMARY ANSWER: The…

Abstract Study question What is the prevalence of endometrial polyps in women with endometriosis and vice versa? Summary answer Available data showed that there is a bidirectional association between endometriosis and endometrial polyps, pa…

Abstract Study question Is IVF more effective than surgery for treating infertility associated to ovarian and deep endometriosis detected at ultrasound? Summary answer The live birth rate within a year from the study’s beginning was signifi…

The ambiguity of current recommendations on the use of oocyte cryopreservation in patients with endometriosis reflects the lack of comprehensive studies evaluating its efficacy. This review seeks to summarize all available data on the outco…

Abstract Study question Does endometriosis affect the cumulative live birth rate in patients undergoing IVF compared to matched controls? Summary answer The cumulative live birth rates of patients with endometriosis are comparable to those …

Abstract Study question How does adenomyosis affect live birth rates (LBR) in women undergoing assisted reproductive technology (ART) compared to a matched control population? Summary answer Women with adenomyosis, matched with controls for…

Abstract Study question Do umbilical vein cord blood hormonal levels differ among pregnant women with endometriosis, polycystic ovarian syndrome (PCOS), and healthy controls delivering singleton female infants? Summary answer Umbilical cord…

OBJECTIVE: To investigate the prevalence of coexisting pelvic lesions in postcesarean bladder endometriosis (BE) and primary BE. If women with postcesarean BE exhibit a lower prevalence of coexistent endometriosis, it could be hypothesized …

STUDY QUESTION: In patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS; population), is the presence of functional endometrium (FE) in uterine remnants (URs) (exposure), compared with the absence of FE in UR/absence of UR (comparis…

STUDY QUESTION: How does adenomyosis affect live birth rates (LBRs) in women undergoing ART compared to a matched control population? SUMMARY ANSWER: Women with adenomyosis, matched with controls for age, blastocyst count, and top-quality …

The use of hormonal treatments for endometriosis has increased in recent years. Their effectiveness lies in creating a stable hormonal environment, reducing peripheral estrogen levels, and suppressing ovulation and menstruation. Although th…

RESEARCH QUESTION: What is the rate of second children among women affected from endometriosis who conceived their first child through Assisted Reproduction Technologies (ARTs)? Are there differences between endometriosis and other causes o…

BACKGROUND: Endometriosis affects women of reproductive age. Increasing attention is being given to the characterization of comorbidities in endometriosis to enhance clinical phenotyping. Among these comorbidities, migraine has been reporte…

Adenomyosis is an important clinical condition with uncertain prevalence, and clinical focus on adenomyosis in patients undergoing assisted reproductive technology (ART) has increased during recent years. Recognizing the limited clinical kn…

Research rarely progresses in a straight line. It is more like an unpredictable front, marked by bursts of brilliance that fade after a few years, sudden breakthroughs, periods of stagnation, rediscoveries of forgotten ideas and occasional …

Objectives: The aim of this study was to review the importance of peritoneal fluid steroid hormone concentrations to understand the mechanism of hormonal medical treatment of endometriosis-associated pain. Design: The study included a PubMe…

Linked article: This Correspondence comments on Knez et al. Click here to view the article.

BACKGROUND: No conceptually new drugs for the safe and successful cure of endometriosis are likely to become available soon. Hormonal modulation of ovarian function and suppression of menstruation remain the pillars of disease control. Howe…

Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood …

The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, hav…

Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ove…

This group was formed out of the conviction that endometriosis research has not progressed at a pace in proportion to disease severity and the negative impact on women's quality of life. Furthermore, advancement in our understanding of this…